In situ mitochondrial biomineralization for drug-free cancer therapy
The common clinical chemotherapy often brings serious side effects to patients, mainly due to the off-target and leakage of toxic drugs. However, this is fatal for some specific clinical tumors, such as brain tumors and neuroma. This study performs a drug-free approach by encapsulating black phospho...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/177912 |
| _version_ | 1811680810257874944 |
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| author | Ma, Zhaoyu Zeng, Pei Zhai, Tianyou Zhao, Yanli Liang, Huageng |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Ma, Zhaoyu Zeng, Pei Zhai, Tianyou Zhao, Yanli Liang, Huageng |
| author_sort | Ma, Zhaoyu |
| collection | NTU |
| description | The common clinical chemotherapy often brings serious side effects to patients, mainly due to the off-target and leakage of toxic drugs. However, this is fatal for some specific clinical tumors, such as brain tumors and neuroma. This study performs a drug-free approach by encapsulating black phosphorus (BP) and calcium peroxide (CaO2) in liposomes with surface-modified triphenylphosphonium (BCLT) to develop mitochondria targeting calcification for cancer therapy without damaging normal cells. BCLT preferentially accumulates inside tumor mitochondria and then is activated by near-infrared (NIR) laser irradiation to produce abundant PO4 3- and Ca2+ to accelerate in situ mitochondrial mineralization, leading to mitochondrial dysfunction and cancer cell death. More importantly, both PO4 3- and Ca2+ are essential components of metabolism in the body, and random gradient diffusion or premature leakage does not cause damage to adjacent normal cells. This achievement promises to be an alternative to conventional chemotherapy in clinical practice for many specific tumor types. |
| first_indexed | 2024-10-01T03:30:58Z |
| format | Journal Article |
| id | ntu-10356/177912 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:30:58Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1779122024-06-03T04:29:03Z In situ mitochondrial biomineralization for drug-free cancer therapy Ma, Zhaoyu Zeng, Pei Zhai, Tianyou Zhao, Yanli Liang, Huageng School of Chemistry, Chemical Engineering and Biotechnology Medicine, Health and Life Sciences Calcification Cancer therapy The common clinical chemotherapy often brings serious side effects to patients, mainly due to the off-target and leakage of toxic drugs. However, this is fatal for some specific clinical tumors, such as brain tumors and neuroma. This study performs a drug-free approach by encapsulating black phosphorus (BP) and calcium peroxide (CaO2) in liposomes with surface-modified triphenylphosphonium (BCLT) to develop mitochondria targeting calcification for cancer therapy without damaging normal cells. BCLT preferentially accumulates inside tumor mitochondria and then is activated by near-infrared (NIR) laser irradiation to produce abundant PO4 3- and Ca2+ to accelerate in situ mitochondrial mineralization, leading to mitochondrial dysfunction and cancer cell death. More importantly, both PO4 3- and Ca2+ are essential components of metabolism in the body, and random gradient diffusion or premature leakage does not cause damage to adjacent normal cells. This achievement promises to be an alternative to conventional chemotherapy in clinical practice for many specific tumor types. National Research Foundation (NRF) This work was supported by the National Natural Science Foundation of China (81927807 and 12174136). This work was also supported by the Singapore National Research Foundation under Its Competitive Research Programme (NRF-CRP26-2021-0002). 2024-06-03T04:29:03Z 2024-06-03T04:29:03Z 2024 Journal Article Ma, Z., Zeng, P., Zhai, T., Zhao, Y. & Liang, H. (2024). In situ mitochondrial biomineralization for drug-free cancer therapy. Advanced Materials, 36(19), e2310218-. https://dx.doi.org/10.1002/adma.202310218 0935-9648 https://hdl.handle.net/10356/177912 10.1002/adma.202310218 38315577 2-s2.0-85184728325 19 36 e2310218 en NRF-CRP26-2021-0002 Advanced Materials © 2024 Wiley-VCH GmbH. All rights reserved. |
| spellingShingle | Medicine, Health and Life Sciences Calcification Cancer therapy Ma, Zhaoyu Zeng, Pei Zhai, Tianyou Zhao, Yanli Liang, Huageng In situ mitochondrial biomineralization for drug-free cancer therapy |
| title | In situ mitochondrial biomineralization for drug-free cancer therapy |
| title_full | In situ mitochondrial biomineralization for drug-free cancer therapy |
| title_fullStr | In situ mitochondrial biomineralization for drug-free cancer therapy |
| title_full_unstemmed | In situ mitochondrial biomineralization for drug-free cancer therapy |
| title_short | In situ mitochondrial biomineralization for drug-free cancer therapy |
| title_sort | in situ mitochondrial biomineralization for drug free cancer therapy |
| topic | Medicine, Health and Life Sciences Calcification Cancer therapy |
| url | https://hdl.handle.net/10356/177912 |
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