Transethosome-based topical administration systems with enhanced penetration and dual actions for treating EGFR-overexpressed cutaneous squamous cell carcinoma
Epidermal growth factor receptor (EGFR)-overexpressing cutaneous squamous cell carcinoma (CSCC) necessitates more effective therapies due to its elevated metastasis risk compared to the conventional CSCC. While photodynamic therapy (PDT) is a promising way to treat CSCC, effectively administering ph...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/177932 |
| _version_ | 1811682133006090240 |
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| author | Wang, Wenyan Tham, Phoebe Huijun Ding, Chendi Huang, Ping Li, Tingxuan Luo, Jingjing Xiang, Huijing Zeng, Xiaowei Chen, Hongzhong Zhao, Yanli |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Wang, Wenyan Tham, Phoebe Huijun Ding, Chendi Huang, Ping Li, Tingxuan Luo, Jingjing Xiang, Huijing Zeng, Xiaowei Chen, Hongzhong Zhao, Yanli |
| author_sort | Wang, Wenyan |
| collection | NTU |
| description | Epidermal growth factor receptor (EGFR)-overexpressing cutaneous squamous cell carcinoma (CSCC) necessitates more effective therapies due to its elevated metastasis risk compared to the conventional CSCC. While photodynamic therapy (PDT) is a promising way to treat CSCC, effectively administering photosensitizers to reach deeper skin malignancies remains a challenge. Herein, BE-TEL is reported, a transethosome formulation designed to enhance skin and cutaneous tumor permeability, for targeted treatment of EGFR-overexpressed CSCC. The formulation is co-loaded with Erlotinib (Erb), a hydrophobic EGFR inhibitor, and BODIPY (BPY), a photosensitizer. Upon skin penetration and subsequent exposure to 660 nm light, BE-TEL induces tumor cell apoptosis by reactive oxygen species (ROS) generation and EGFR pathway inhibition. ROS and Erb-induced metabolic oxidative stress by upregulating the expression of NADPH oxidase 4 (NOX4) can enhance immunogenic cell death (ICD) and promote dendritic cell maturation for tumor-specific immune response. Furthermore, the EGFR downregulation further mitigated the risk of metastasis and recurrence. In conclusion, BE-TEL's superior penetration ability together with its combined PDT and EGFR targeted approach paves the way for an efficient strategy against EGFR-overexpressed CSCC. |
| first_indexed | 2024-10-01T03:51:59Z |
| format | Journal Article |
| id | ntu-10356/177932 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:51:59Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1779322024-06-03T05:40:36Z Transethosome-based topical administration systems with enhanced penetration and dual actions for treating EGFR-overexpressed cutaneous squamous cell carcinoma Wang, Wenyan Tham, Phoebe Huijun Ding, Chendi Huang, Ping Li, Tingxuan Luo, Jingjing Xiang, Huijing Zeng, Xiaowei Chen, Hongzhong Zhao, Yanli School of Chemistry, Chemical Engineering and Biotechnology A*STAR Skin Research Labs Medicine, Health and Life Sciences Cutaneous squamous cell carcinoma EGFR inhibitor Epidermal growth factor receptor (EGFR)-overexpressing cutaneous squamous cell carcinoma (CSCC) necessitates more effective therapies due to its elevated metastasis risk compared to the conventional CSCC. While photodynamic therapy (PDT) is a promising way to treat CSCC, effectively administering photosensitizers to reach deeper skin malignancies remains a challenge. Herein, BE-TEL is reported, a transethosome formulation designed to enhance skin and cutaneous tumor permeability, for targeted treatment of EGFR-overexpressed CSCC. The formulation is co-loaded with Erlotinib (Erb), a hydrophobic EGFR inhibitor, and BODIPY (BPY), a photosensitizer. Upon skin penetration and subsequent exposure to 660 nm light, BE-TEL induces tumor cell apoptosis by reactive oxygen species (ROS) generation and EGFR pathway inhibition. ROS and Erb-induced metabolic oxidative stress by upregulating the expression of NADPH oxidase 4 (NOX4) can enhance immunogenic cell death (ICD) and promote dendritic cell maturation for tumor-specific immune response. Furthermore, the EGFR downregulation further mitigated the risk of metastasis and recurrence. In conclusion, BE-TEL's superior penetration ability together with its combined PDT and EGFR targeted approach paves the way for an efficient strategy against EGFR-overexpressed CSCC. National Research Foundation (NRF) The authors sincerely acknowledge the financial support provided by the National Natural Science Foundation of China (32101065) and the National Research Foundation Singapore under Its Competitive Research Programme (NRF-CRP26-2021-0002). 2024-06-03T05:40:36Z 2024-06-03T05:40:36Z 2024 Journal Article Wang, W., Tham, P. H., Ding, C., Huang, P., Li, T., Luo, J., Xiang, H., Zeng, X., Chen, H. & Zhao, Y. (2024). Transethosome-based topical administration systems with enhanced penetration and dual actions for treating EGFR-overexpressed cutaneous squamous cell carcinoma. Advanced Functional Materials, 2312838-. https://dx.doi.org/10.1002/adfm.202312838 1616-301X https://hdl.handle.net/10356/177932 10.1002/adfm.202312838 2-s2.0-85185189741 2312838 en NRF-CRP26-2021-0002 Advanced Functional Materials © 2024 Wiley-VCH GmbH. All rights reserved. |
| spellingShingle | Medicine, Health and Life Sciences Cutaneous squamous cell carcinoma EGFR inhibitor Wang, Wenyan Tham, Phoebe Huijun Ding, Chendi Huang, Ping Li, Tingxuan Luo, Jingjing Xiang, Huijing Zeng, Xiaowei Chen, Hongzhong Zhao, Yanli Transethosome-based topical administration systems with enhanced penetration and dual actions for treating EGFR-overexpressed cutaneous squamous cell carcinoma |
| title | Transethosome-based topical administration systems with enhanced penetration and dual actions for treating EGFR-overexpressed cutaneous squamous cell carcinoma |
| title_full | Transethosome-based topical administration systems with enhanced penetration and dual actions for treating EGFR-overexpressed cutaneous squamous cell carcinoma |
| title_fullStr | Transethosome-based topical administration systems with enhanced penetration and dual actions for treating EGFR-overexpressed cutaneous squamous cell carcinoma |
| title_full_unstemmed | Transethosome-based topical administration systems with enhanced penetration and dual actions for treating EGFR-overexpressed cutaneous squamous cell carcinoma |
| title_short | Transethosome-based topical administration systems with enhanced penetration and dual actions for treating EGFR-overexpressed cutaneous squamous cell carcinoma |
| title_sort | transethosome based topical administration systems with enhanced penetration and dual actions for treating egfr overexpressed cutaneous squamous cell carcinoma |
| topic | Medicine, Health and Life Sciences Cutaneous squamous cell carcinoma EGFR inhibitor |
| url | https://hdl.handle.net/10356/177932 |
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