Decision matrix for integrating 3D printing technologies for biomanufacturing of alternative testing model
The ethical concerns surrounding the use of animals in cosmetics testing have spurred the demand for alternative test models. Digital manufacturing, often denoted as 3D printing, presents a compelling and cost-effective avenue for fabricating such testing models. The current manuscript proposes a di...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/178162 |
| _version_ | 1826110012613722112 |
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| author | Lee, Jia Min Tan, Ming Jie Ma, Wai Cheung Yeong, Wai Yee |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Lee, Jia Min Tan, Ming Jie Ma, Wai Cheung Yeong, Wai Yee |
| author_sort | Lee, Jia Min |
| collection | NTU |
| description | The ethical concerns surrounding the use of animals in cosmetics testing have spurred the demand for alternative test models. Digital manufacturing, often denoted as 3D printing, presents a compelling and cost-effective avenue for fabricating such testing models. The current manuscript proposes a digitally manufactured alternative testing platform that comprises three main components: bioprinted skin model, platform fabrication and electronic printing. For the first time, we assessed bioprinted skin models for the intention for use in cosmetic testing. We employed OECD guidelines to test on the skin model’s responsiveness to anti-ageing products and irritant compounds. Our studies showed the efficacy of our bioprinted skin model capable of evaluating cosmetic compounds. An evaluation matrix was used to select the appropriate digital manufacturing technology to fabricate the setup for alternative testing model. Multi-material jetting was selected as the most appropriate additive manufacturing technology to introduce modularity and water-tight designs for the test platform. We have also introduced an electronic component in the test platform fabricated using electronic printing to provide localised heating on the skin model. Overall, this study highlights the potential of digital manufacturing and biomanufacturing to promote ethical and sustainable practices in cosmetic testing. Moreover, the decision matrix showcase in this study will be beneficial for scientists and researchers in application-driven selection on 3D printing technology. |
| first_indexed | 2024-10-01T02:27:51Z |
| format | Journal Article |
| id | ntu-10356/178162 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:27:51Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1781622024-06-05T04:17:31Z Decision matrix for integrating 3D printing technologies for biomanufacturing of alternative testing model Lee, Jia Min Tan, Ming Jie Ma, Wai Cheung Yeong, Wai Yee School of Mechanical and Aerospace Engineering Singapore Centre for 3D Printing Engineering Bioprinting Digital manufacturing integration The ethical concerns surrounding the use of animals in cosmetics testing have spurred the demand for alternative test models. Digital manufacturing, often denoted as 3D printing, presents a compelling and cost-effective avenue for fabricating such testing models. The current manuscript proposes a digitally manufactured alternative testing platform that comprises three main components: bioprinted skin model, platform fabrication and electronic printing. For the first time, we assessed bioprinted skin models for the intention for use in cosmetic testing. We employed OECD guidelines to test on the skin model’s responsiveness to anti-ageing products and irritant compounds. Our studies showed the efficacy of our bioprinted skin model capable of evaluating cosmetic compounds. An evaluation matrix was used to select the appropriate digital manufacturing technology to fabricate the setup for alternative testing model. Multi-material jetting was selected as the most appropriate additive manufacturing technology to introduce modularity and water-tight designs for the test platform. We have also introduced an electronic component in the test platform fabricated using electronic printing to provide localised heating on the skin model. Overall, this study highlights the potential of digital manufacturing and biomanufacturing to promote ethical and sustainable practices in cosmetic testing. Moreover, the decision matrix showcase in this study will be beneficial for scientists and researchers in application-driven selection on 3D printing technology. Nanyang Technological University National Research Foundation (NRF) This research is supported by NAMIC Singapore and funded by the National Research Foundation Singapore under its Innovation Cluster Programme. This work is also supported by the Singapore Centre for 3D Printing, Nanyang Technological University, Singapore, through the use of its additive manufacturing facilities. Funding awardee: Wai Yee Yeong. 2024-06-05T04:17:31Z 2024-06-05T04:17:31Z 2024 Journal Article Lee, J. M., Tan, M. J., Ma, W. C. & Yeong, W. Y. (2024). Decision matrix for integrating 3D printing technologies for biomanufacturing of alternative testing model. International Journal of Advanced Manufacturing Technology, 130(9-10), 4137-4149. https://dx.doi.org/10.1007/s00170-024-12966-5 0268-3768 https://hdl.handle.net/10356/178162 10.1007/s00170-024-12966-5 2-s2.0-85182217220 9-10 130 4137 4149 en International Journal of Advanced Manufacturing Technology © 2024 The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature. All rights reserved. |
| spellingShingle | Engineering Bioprinting Digital manufacturing integration Lee, Jia Min Tan, Ming Jie Ma, Wai Cheung Yeong, Wai Yee Decision matrix for integrating 3D printing technologies for biomanufacturing of alternative testing model |
| title | Decision matrix for integrating 3D printing technologies for biomanufacturing of alternative testing model |
| title_full | Decision matrix for integrating 3D printing technologies for biomanufacturing of alternative testing model |
| title_fullStr | Decision matrix for integrating 3D printing technologies for biomanufacturing of alternative testing model |
| title_full_unstemmed | Decision matrix for integrating 3D printing technologies for biomanufacturing of alternative testing model |
| title_short | Decision matrix for integrating 3D printing technologies for biomanufacturing of alternative testing model |
| title_sort | decision matrix for integrating 3d printing technologies for biomanufacturing of alternative testing model |
| topic | Engineering Bioprinting Digital manufacturing integration |
| url | https://hdl.handle.net/10356/178162 |
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