Interaction of TRF2-Rap1 with telomeric chromatin in the context of aging and cancer
Telomeric DNA form the ends of eukaryotic DNA. It is a tandem array of [TTAGGG]n, with a 3’ G-rich overhang. Telomeric nucleosomes form unique nucleoprotein structures with the shelterin complex consisting of 6 components; TRF1, TRF2, POT1, RAP1, TIN2, TPP1. Shelterin plays a crucial role in prevent...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
Nanyang Technological University
2024
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/178191 |