Investigation of mechanisms underlying obesity amongst Chinese, Malays and Indians in Singapore
In Singapore, Malays and Indians exhibit higher obesity susceptibility compared to the Chinese. I investigated whether genetic, dietary, physical activity, sleep and gut microbial factors could explain this disparity. Whole genome sequencing data and lifestyle traits quantified using validated quest...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2024
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| Online Access: | https://hdl.handle.net/10356/178223 |
| _version_ | 1826113278168793088 |
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| author | Lam, Benjamin Chih Chiang |
| author2 | John Chambers |
| author_facet | John Chambers Lam, Benjamin Chih Chiang |
| author_sort | Lam, Benjamin Chih Chiang |
| collection | NTU |
| description | In Singapore, Malays and Indians exhibit higher obesity susceptibility compared to the Chinese. I investigated whether genetic, dietary, physical activity, sleep and gut microbial factors could explain this disparity. Whole genome sequencing data and lifestyle traits quantified using validated questionnaires of ~10,000 individuals were utilized. Gut microbial factors based on shotgun metagenomic data were studied for their relationship with adiposity and adiposity loss post lifestyle-intervention. There were no significant differences in risk allele frequencies and effect sizes of BMI-related variants. Polygenic risk score, saturated fat and fiber consumption, engagement in vigorous physical activities, duration and quality of sleep, snoring, Eggerthella lenta, Klebsiella grimontii, as well as three microbial pathways (involving fatty acid and membrane component synthesis) were all significantly associated with adiposity. However, these factors did not fully explain the higher obesity rates in Malays and Indians. More research is needed to explore other mechanisms underlying adiposity within Asian populations. (150 words) |
| first_indexed | 2024-10-01T03:20:36Z |
| format | Thesis-Doctor of Philosophy |
| id | ntu-10356/178223 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:20:36Z |
| publishDate | 2024 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1782232024-06-09T15:39:04Z Investigation of mechanisms underlying obesity amongst Chinese, Malays and Indians in Singapore Lam, Benjamin Chih Chiang John Chambers Marie Loh Chiew Shia Lee Kong Chian School of Medicine (LKCMedicine) Niranjan Nagarajan john.chambers@ntu.edu.sg, marie_loh@ntu.edu.sg, nagarajann@gis.a-star.edu.sg Medicine, Health and Life Sciences Obesity Obesity in Singapore In Singapore, Malays and Indians exhibit higher obesity susceptibility compared to the Chinese. I investigated whether genetic, dietary, physical activity, sleep and gut microbial factors could explain this disparity. Whole genome sequencing data and lifestyle traits quantified using validated questionnaires of ~10,000 individuals were utilized. Gut microbial factors based on shotgun metagenomic data were studied for their relationship with adiposity and adiposity loss post lifestyle-intervention. There were no significant differences in risk allele frequencies and effect sizes of BMI-related variants. Polygenic risk score, saturated fat and fiber consumption, engagement in vigorous physical activities, duration and quality of sleep, snoring, Eggerthella lenta, Klebsiella grimontii, as well as three microbial pathways (involving fatty acid and membrane component synthesis) were all significantly associated with adiposity. However, these factors did not fully explain the higher obesity rates in Malays and Indians. More research is needed to explore other mechanisms underlying adiposity within Asian populations. (150 words) Doctor of Philosophy 2024-06-06T05:44:25Z 2024-06-06T05:44:25Z 2024 Thesis-Doctor of Philosophy Lam, B. C. C. (2024). Investigation of mechanisms underlying obesity amongst Chinese, Malays and Indians in Singapore. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/178223 https://hdl.handle.net/10356/178223 en NMRC/MOH-000148-00 HELIOS-EDC2/18002 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University |
| spellingShingle | Medicine, Health and Life Sciences Obesity Obesity in Singapore Lam, Benjamin Chih Chiang Investigation of mechanisms underlying obesity amongst Chinese, Malays and Indians in Singapore |
| title | Investigation of mechanisms underlying obesity amongst Chinese, Malays and Indians in Singapore |
| title_full | Investigation of mechanisms underlying obesity amongst Chinese, Malays and Indians in Singapore |
| title_fullStr | Investigation of mechanisms underlying obesity amongst Chinese, Malays and Indians in Singapore |
| title_full_unstemmed | Investigation of mechanisms underlying obesity amongst Chinese, Malays and Indians in Singapore |
| title_short | Investigation of mechanisms underlying obesity amongst Chinese, Malays and Indians in Singapore |
| title_sort | investigation of mechanisms underlying obesity amongst chinese malays and indians in singapore |
| topic | Medicine, Health and Life Sciences Obesity Obesity in Singapore |
| url | https://hdl.handle.net/10356/178223 |
| work_keys_str_mv | AT lambenjaminchihchiang investigationofmechanismsunderlyingobesityamongstchinesemalaysandindiansinsingapore |