14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway

14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway

The cAMP/PKA and mitogen-activated protein kinase (MAPK) signaling cascade control many cellular processes and are highly regulated for optimal cellular responses upon external stimuli. Phosphodiesterase 8A (PDE8A) is an important regulator that inhibits signaling via cAMP-dependent PKA by hydrolyzi...

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Bibliographic Details
Main Authors: Mukherjee, Soumita, Roy, Somesh, Mukherjee, Shruti, Harikishore, Amaravadhi, Bhunia, Anirban, Mandal, Atin K.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
CRAF kinase
Phosphodiesterase
Online Access:https://hdl.handle.net/10356/178406

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