Strategies for constructing seven-membered rings: applications in natural product synthesis
The seven-membered ring motifs are found in bioactive pharmaceuticals and a wide range of natural products, including alkaloids and terpenoids, which hold significant importance in synthetic chemistry and has garnered considerable attention from both academia and industry. Despite the challenges fac...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/178409 |
| _version_ | 1826125954788884480 |
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| author | Chen, Peng Liang, Lijuan Zhu, Yufei Xing, Zhimin Jia, Zhenhua Loh, Teck-Peng |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Chen, Peng Liang, Lijuan Zhu, Yufei Xing, Zhimin Jia, Zhenhua Loh, Teck-Peng |
| author_sort | Chen, Peng |
| collection | NTU |
| description | The seven-membered ring motifs are found in bioactive pharmaceuticals and a wide range of natural products, including alkaloids and terpenoids, which hold significant importance in synthetic chemistry and has garnered considerable attention from both academia and industry. Despite the challenges faced in the past decade, the total synthesis of natural products incorporating the non-aromatic cycloheptane skeletons remains a compelling pursuit. Recently, numerous elegant strategies for constructing the seven-membered ring system have been successfully developed. This review focuses on the recent advancements in this field from 2017 to April 2023, highlighting key transformations utilized to construct the non-aromatic cycloheptane core structures and serves as a valuable guide for synthetic chemists engaged in the total synthesis of natural products containing seven-membered ring motifs. |
| first_indexed | 2024-10-01T06:44:51Z |
| format | Journal Article |
| id | ntu-10356/178409 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:44:51Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1784092024-06-21T15:31:50Z Strategies for constructing seven-membered rings: applications in natural product synthesis Chen, Peng Liang, Lijuan Zhu, Yufei Xing, Zhimin Jia, Zhenhua Loh, Teck-Peng School of Chemistry, Chemical Engineering and Biotechnology Chemistry Seven-membered rings Total synthesis The seven-membered ring motifs are found in bioactive pharmaceuticals and a wide range of natural products, including alkaloids and terpenoids, which hold significant importance in synthetic chemistry and has garnered considerable attention from both academia and industry. Despite the challenges faced in the past decade, the total synthesis of natural products incorporating the non-aromatic cycloheptane skeletons remains a compelling pursuit. Recently, numerous elegant strategies for constructing the seven-membered ring system have been successfully developed. This review focuses on the recent advancements in this field from 2017 to April 2023, highlighting key transformations utilized to construct the non-aromatic cycloheptane core structures and serves as a valuable guide for synthetic chemists engaged in the total synthesis of natural products containing seven-membered ring motifs. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) Nanyang Technological University Submitted/Accepted version We thank the financial support from the Start-up Grant of Henan University of Technology (No. 0004/31401540). T.-P. Loh thank the financial support from Distinguished University Professor Grant (Nanyang Technological University), AcRF Tier 1 grants from the Ministry of Education of Singapore (Nos. RG 107/19, RG 11/20 and RT 14/20), and the Agency for Science, Technology and Research (A∗STAR) under its MTC Individual Research Grants (No. M21K2c0114). 2024-06-18T07:36:28Z 2024-06-18T07:36:28Z 2024 Journal Article Chen, P., Liang, L., Zhu, Y., Xing, Z., Jia, Z. & Loh, T. (2024). Strategies for constructing seven-membered rings: applications in natural product synthesis. Chinese Chemical Letters, 35(6), 109229-. https://dx.doi.org/10.1016/j.cclet.2023.109229 1001-8417 https://hdl.handle.net/10356/178409 10.1016/j.cclet.2023.109229 2-s2.0-85188657582 6 35 109229 en RG 107/19 RG 11/20 RT 14/20 M21K2c0114 Chinese Chemical Letters © 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1016/j.cclet.2023.109229. application/pdf |
| spellingShingle | Chemistry Seven-membered rings Total synthesis Chen, Peng Liang, Lijuan Zhu, Yufei Xing, Zhimin Jia, Zhenhua Loh, Teck-Peng Strategies for constructing seven-membered rings: applications in natural product synthesis |
| title | Strategies for constructing seven-membered rings: applications in natural product synthesis |
| title_full | Strategies for constructing seven-membered rings: applications in natural product synthesis |
| title_fullStr | Strategies for constructing seven-membered rings: applications in natural product synthesis |
| title_full_unstemmed | Strategies for constructing seven-membered rings: applications in natural product synthesis |
| title_short | Strategies for constructing seven-membered rings: applications in natural product synthesis |
| title_sort | strategies for constructing seven membered rings applications in natural product synthesis |
| topic | Chemistry Seven-membered rings Total synthesis |
| url | https://hdl.handle.net/10356/178409 |
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