Visual cognitive assessment test: utility of the brief cognitive battery for early screening of cognitive impairment in Chongqing, China
Objectives: Early detection of cognitive impairment is essential for timely intervention. Currently, most widely used cognitive screening tests are influenced by language and cultural differences; therefore, there is a need for the development of a language-neutral, visual-based cognitive assessment...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/178524 |
| _version_ | 1811679298777513984 |
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| author | Liu, Yidan Xie, Binbin Li, Qin Xiao, Shufang Li, Jiamin Kandiah, Nagaendran Ng, Kok Pin Jiang, Liumi Li, Xiaofeng |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Liu, Yidan Xie, Binbin Li, Qin Xiao, Shufang Li, Jiamin Kandiah, Nagaendran Ng, Kok Pin Jiang, Liumi Li, Xiaofeng |
| author_sort | Liu, Yidan |
| collection | NTU |
| description | Objectives: Early detection of cognitive impairment is essential for timely intervention. Currently, most widely used cognitive screening tests are influenced by language and cultural differences; therefore, there is a need for the development of a language-neutral, visual-based cognitive assessment tool. The Visual Cognitive Assessment Test (VCAT), a 30-point test that assesses memory, executive function, visuospatial function, attention, and language, has demonstrated its utility in a multilingual population. In this study, we evaluated the reliability, validity, and diagnostic performance of the VCAT for screening early cognitive impairment in Chongqing, China. Methods: A total of 134 individuals (49 healthy controls (HCs), 52 with mild cognitive impairment (MCI), and 33 with mild dementia) completed the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), VCAT, and domain-specific neuropsychological assessments. The diagnostic performances of MMSE, MoCA, and VCAT were evaluated using the area under the curve (AUC), sensitivity, and specificity. Construct validity of the VCAT was assessed with well-established domain-specific cognitive assessments. Reliability was measured using Cronbach's alpha. Results: The VCAT and its subdomains demonstrated both good construct validity and internal consistency (α = 0.577). The performance of VCAT was comparable to that of MoCA and MMSE in differentiating mild dementia from nondemented groups (AUC: 0.940 vs. 0.902 and 0.977, respectively; p =.098 and.053) and in distinguishing cognitive impairment (CI) from HC (AUC: 0.929 vs. 0.899 and 0.891, respectively; p =.239 and.161), adjusted for education level. The optimal score range for VCAT in determining dementia, MCI, and HC was 0–14, 15–19, and 20–30, respectively. Conclusion: The VCAT proves to be a reliable screening test for early cognitive impairment within our cohort. Being both language and cultural neutral, the VCAT has the potential to be utilized among a wider population within China. |
| first_indexed | 2024-10-01T03:06:56Z |
| format | Journal Article |
| id | ntu-10356/178524 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:06:56Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1785242024-06-30T15:39:26Z Visual cognitive assessment test: utility of the brief cognitive battery for early screening of cognitive impairment in Chongqing, China Liu, Yidan Xie, Binbin Li, Qin Xiao, Shufang Li, Jiamin Kandiah, Nagaendran Ng, Kok Pin Jiang, Liumi Li, Xiaofeng Lee Kong Chian School of Medicine (LKCMedicine) National Neuroscience Institute Duke-NUS Medical School Medicine, Health and Life Sciences Cognitive impairment Diagnostic value Objectives: Early detection of cognitive impairment is essential for timely intervention. Currently, most widely used cognitive screening tests are influenced by language and cultural differences; therefore, there is a need for the development of a language-neutral, visual-based cognitive assessment tool. The Visual Cognitive Assessment Test (VCAT), a 30-point test that assesses memory, executive function, visuospatial function, attention, and language, has demonstrated its utility in a multilingual population. In this study, we evaluated the reliability, validity, and diagnostic performance of the VCAT for screening early cognitive impairment in Chongqing, China. Methods: A total of 134 individuals (49 healthy controls (HCs), 52 with mild cognitive impairment (MCI), and 33 with mild dementia) completed the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), VCAT, and domain-specific neuropsychological assessments. The diagnostic performances of MMSE, MoCA, and VCAT were evaluated using the area under the curve (AUC), sensitivity, and specificity. Construct validity of the VCAT was assessed with well-established domain-specific cognitive assessments. Reliability was measured using Cronbach's alpha. Results: The VCAT and its subdomains demonstrated both good construct validity and internal consistency (α = 0.577). The performance of VCAT was comparable to that of MoCA and MMSE in differentiating mild dementia from nondemented groups (AUC: 0.940 vs. 0.902 and 0.977, respectively; p =.098 and.053) and in distinguishing cognitive impairment (CI) from HC (AUC: 0.929 vs. 0.899 and 0.891, respectively; p =.239 and.161), adjusted for education level. The optimal score range for VCAT in determining dementia, MCI, and HC was 0–14, 15–19, and 20–30, respectively. Conclusion: The VCAT proves to be a reliable screening test for early cognitive impairment within our cohort. Being both language and cultural neutral, the VCAT has the potential to be utilized among a wider population within China. Published version Science and technology program projects of the Ninth People’s Hospital of Chongqing, Grant/Award Number: 2021YJXM10; Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University, Grant/Award Number: 1; Chongqing Natural Science Fund Project, Grant/Award Number:cstc2019jcyj-zdxmX0029. 2024-06-25T04:43:24Z 2024-06-25T04:43:24Z 2024 Journal Article Liu, Y., Xie, B., Li, Q., Xiao, S., Li, J., Kandiah, N., Ng, K. P., Jiang, L. & Li, X. (2024). Visual cognitive assessment test: utility of the brief cognitive battery for early screening of cognitive impairment in Chongqing, China. Brain and Behavior, 14(2), e3413-. https://dx.doi.org/10.1002/brb3.3413 2162-3279 https://hdl.handle.net/10356/178524 10.1002/brb3.3413 38578197 2-s2.0-85184224251 2 14 e3413 en Brain and Behavior © 2024 The Authors. Brain and Behavior published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Cognitive impairment Diagnostic value Liu, Yidan Xie, Binbin Li, Qin Xiao, Shufang Li, Jiamin Kandiah, Nagaendran Ng, Kok Pin Jiang, Liumi Li, Xiaofeng Visual cognitive assessment test: utility of the brief cognitive battery for early screening of cognitive impairment in Chongqing, China |
| title | Visual cognitive assessment test: utility of the brief cognitive battery for early screening of cognitive impairment in Chongqing, China |
| title_full | Visual cognitive assessment test: utility of the brief cognitive battery for early screening of cognitive impairment in Chongqing, China |
| title_fullStr | Visual cognitive assessment test: utility of the brief cognitive battery for early screening of cognitive impairment in Chongqing, China |
| title_full_unstemmed | Visual cognitive assessment test: utility of the brief cognitive battery for early screening of cognitive impairment in Chongqing, China |
| title_short | Visual cognitive assessment test: utility of the brief cognitive battery for early screening of cognitive impairment in Chongqing, China |
| title_sort | visual cognitive assessment test utility of the brief cognitive battery for early screening of cognitive impairment in chongqing china |
| topic | Medicine, Health and Life Sciences Cognitive impairment Diagnostic value |
| url | https://hdl.handle.net/10356/178524 |
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