Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover

Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover

Hutchinson-Gilford Progeria syndrome (HGPS) is a severe premature ageing disorder caused by a 50 amino acid truncated (Δ50AA) and permanently farnesylated lamin A (LA) mutant called progerin. On a cellular level, progerin expression leads to heterochromatin loss, impaired nucleocytoplasmic transport...

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Bibliographic Details
Main Authors: Foo, Mattheus Xing Rong, Ong, Peh Fern, Yap, Zi Xuan, Maric, Martina, Bong, Christopher Jue Shi, Dröge, Peter, Burke, Brian, Dreesen, Oliver
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
DNA damage
Farnesyltransferase inhibitor
Online Access:https://hdl.handle.net/10356/178571

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