Structural basis of human NOX5 activation

Structural basis of human NOX5 activation

NADPH oxidase 5 (NOX5) catalyzes the production of superoxide free radicals and regulates physiological processes from sperm motility to cardiac rhythm. Overexpression of NOX5 leads to cancers, diabetes, and cardiovascular diseases. NOX5 is activated by intracellular calcium signaling, but the under...

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Bibliographic Details
Main Authors: Cui, Chenxi, Jiang, Meiqin, Jain, Nikhil, Das, Sourav, Lo, Yu-Hua, Kermani, Ali A., Pipatpolkai, Tanadet, Sun, Ji
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2024
Subjects:
Physics
Conformational transition
Cryoelectron microscopy
Online Access:https://hdl.handle.net/10356/178825

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