Age-related decline in thickness and surface area in the cortical surface and hippocampus: lifespan trajectories and decade-by-decade analyses
Previous studies on age-related changes in cortical and hippocampal morphology were not designed or able to reveal the complex spatial patterns of changes across the lifespan. To this end, the current study examined these changes in a decade-by-decade manner by comparing consecutive age decades at t...
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| Format: | Journal Article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/10356/178860 |
| _version_ | 1811686591363547136 |
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| author | Yu, Junhong |
| author2 | School of Social Sciences |
| author_facet | School of Social Sciences Yu, Junhong |
| author_sort | Yu, Junhong |
| collection | NTU |
| description | Previous studies on age-related changes in cortical and hippocampal morphology were not designed or able to reveal the complex spatial patterns of changes across the lifespan. To this end, the current study examined these changes in a decade-by-decade manner by comparing consecutive age decades at the vertex-wise level. Additionally, the lifespan trajectories of cortical/hippocampal mean thickness and total surface area were modeled and plotted out to provide an overview of their age-related changes. Using two lifespan datasets (Ntotal = 1378; 18 ≤ age ≤ 100), vertex-wise thickness and surface area measurements were extracted from the cortical and unfolded hippocampal surfaces and analyzed using whole-brain/hippocampus vertex-wise analyses. Lifespan trajectories of cortical/hippocampal mean thickness and total surface area were modeled with generalized additive models for location, scale, and shape. These models revealed fairly linear declines in both cortical measures and inverted U-shaped trajectories for both hippocampal measures. Across the different age decades, the sizes and locations of cortical thinning clusters were highly variable across the age decades. No significant clusters of cortical surface area changes were observed across the age decades. Significant clusters of hippocampal surface area and thickness reduction were not observed until the 70s. Generally, the agreement between datasets on the hippocampal findings was much higher than those of the cortical surface. These findings revealed important nuances in the age-related changes of cortical and hippocampal morphology and cautioned against using lifespan trajectories to infer decade-by-decade changes in the cortical surface and the hippocampus. |
| first_indexed | 2024-10-01T05:02:51Z |
| format | Journal Article |
| id | ntu-10356/178860 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:02:51Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1788602024-07-14T15:30:20Z Age-related decline in thickness and surface area in the cortical surface and hippocampus: lifespan trajectories and decade-by-decade analyses Yu, Junhong School of Social Sciences Social Sciences Aging Cortical surface area Previous studies on age-related changes in cortical and hippocampal morphology were not designed or able to reveal the complex spatial patterns of changes across the lifespan. To this end, the current study examined these changes in a decade-by-decade manner by comparing consecutive age decades at the vertex-wise level. Additionally, the lifespan trajectories of cortical/hippocampal mean thickness and total surface area were modeled and plotted out to provide an overview of their age-related changes. Using two lifespan datasets (Ntotal = 1378; 18 ≤ age ≤ 100), vertex-wise thickness and surface area measurements were extracted from the cortical and unfolded hippocampal surfaces and analyzed using whole-brain/hippocampus vertex-wise analyses. Lifespan trajectories of cortical/hippocampal mean thickness and total surface area were modeled with generalized additive models for location, scale, and shape. These models revealed fairly linear declines in both cortical measures and inverted U-shaped trajectories for both hippocampal measures. Across the different age decades, the sizes and locations of cortical thinning clusters were highly variable across the age decades. No significant clusters of cortical surface area changes were observed across the age decades. Significant clusters of hippocampal surface area and thickness reduction were not observed until the 70s. Generally, the agreement between datasets on the hippocampal findings was much higher than those of the cortical surface. These findings revealed important nuances in the age-related changes of cortical and hippocampal morphology and cautioned against using lifespan trajectories to infer decade-by-decade changes in the cortical surface and the hippocampus. Nanyang Technological University Submitted/Accepted version Junhong Yu is supported by the Nanyang Assistant Professorship (Award no. 021080\u201300001). The HCP Aging data used in the preparation of this manuscript were obtained from the National Institute of Mental Health (NIMH) Data Archive (NDA). NDA is a collaborative informatics system created by the National Institutes of Health to provide a national resource to support and accelerate research in mental health. This manuscript reflects the views of the authors and may not reflect the opinions or views of the NIH or of the submitters submitting original data to NDA. The HCP Aging study was supported by the National Institute On Aging of the National Institutes of Health under Award Number U01AG052564 and by funds provided by the McDonnell Center for Systems Neuroscience at Washington University in St. Louis. Data collection and sharing for the Cam-CAN dataset was funded by the UK Biotechnology and Biological Sciences Research Council (grant number BB/H008217/1), together with support from the UK Medical Research Council and the University of Cambridge, UK. 2024-07-09T05:42:04Z 2024-07-09T05:42:04Z 2024 Journal Article Yu, J. (2024). Age-related decline in thickness and surface area in the cortical surface and hippocampus: lifespan trajectories and decade-by-decade analyses. GeroScience. https://dx.doi.org/10.1007/s11357-024-01220-1 2509-2715 https://hdl.handle.net/10356/178860 10.1007/s11357-024-01220-1 38831181 2-s2.0-85195200173 en GeroScience © 2024 The Author(s), under exclusive licence to American Aging Association. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at: http://dx.doi.org/10.1007/s11357-024-01220-1. application/pdf |
| spellingShingle | Social Sciences Aging Cortical surface area Yu, Junhong Age-related decline in thickness and surface area in the cortical surface and hippocampus: lifespan trajectories and decade-by-decade analyses |
| title | Age-related decline in thickness and surface area in the cortical surface and hippocampus: lifespan trajectories and decade-by-decade analyses |
| title_full | Age-related decline in thickness and surface area in the cortical surface and hippocampus: lifespan trajectories and decade-by-decade analyses |
| title_fullStr | Age-related decline in thickness and surface area in the cortical surface and hippocampus: lifespan trajectories and decade-by-decade analyses |
| title_full_unstemmed | Age-related decline in thickness and surface area in the cortical surface and hippocampus: lifespan trajectories and decade-by-decade analyses |
| title_short | Age-related decline in thickness and surface area in the cortical surface and hippocampus: lifespan trajectories and decade-by-decade analyses |
| title_sort | age related decline in thickness and surface area in the cortical surface and hippocampus lifespan trajectories and decade by decade analyses |
| topic | Social Sciences Aging Cortical surface area |
| url | https://hdl.handle.net/10356/178860 |
| work_keys_str_mv | AT yujunhong agerelateddeclineinthicknessandsurfaceareainthecorticalsurfaceandhippocampuslifespantrajectoriesanddecadebydecadeanalyses |