The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging
Alterations in grey matter (GM) and white matter (WM) are associated with memory impairment across the neurocognitive aging spectrum and theorised to spread throughout brain networks. Functional and structural connectivity (FC,SC) may explain widespread atrophy. We tested the effect of SC and FC to...
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| Format: | Journal Article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/10356/178988 |
| _version_ | 1826129183912230912 |
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| author | Billaud, Charly Hugo Alexandre Yu, Junhong |
| author2 | School of Social Sciences |
| author_facet | School of Social Sciences Billaud, Charly Hugo Alexandre Yu, Junhong |
| author_sort | Billaud, Charly Hugo Alexandre |
| collection | NTU |
| description | Alterations in grey matter (GM) and white matter (WM) are associated with memory impairment across the neurocognitive aging spectrum and theorised to spread throughout brain networks. Functional and structural connectivity (FC,SC) may explain widespread atrophy. We tested the effect of SC and FC to the hippocampus on cortical thickness (CT) of connected areas. In 419 (223 F) participants (agemean=73 ± 8) from the Alzheimer's Disease Neuroimaging Initiative, cortical regions associated with memory (Rey Auditory Verbal Learning Test) were identified using Lasso regression. Two structural equation models (SEM), for SC and resting-state FC, were fitted including CT areas, and SC and FC to the left and right hippocampus (LHIP,RHIP). LHIP (β=-0.150,p=<.001) and RHIP (β=-0.139,p=<.001) SC predicted left temporopolar/rhinal CT; RHIP SC predicted right temporopolar/rhinal CT (β=-0.191,p=<.001). LHIP SC predicted right fusiform/parahippocampal (β=-0.104,p=.011) and intraparietal sulcus/superior parietal CT (β=0.101,p=.028). Increased RHIP FC predicted higher left inferior parietal CT (β=0.132,p=.042) while increased LHIP FC predicted lower right fusiform/parahippocampal CT (β=-0.97; p=.023). The hippocampi may be epicentres for cortical thinning through disrupted connectivity. |
| first_indexed | 2024-10-01T07:36:32Z |
| format | Journal Article |
| id | ntu-10356/178988 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:36:32Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1789882024-07-21T15:30:27Z The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging Billaud, Charly Hugo Alexandre Yu, Junhong School of Social Sciences Social Sciences Alzheimer’s disease Mild cognitive impairment Alterations in grey matter (GM) and white matter (WM) are associated with memory impairment across the neurocognitive aging spectrum and theorised to spread throughout brain networks. Functional and structural connectivity (FC,SC) may explain widespread atrophy. We tested the effect of SC and FC to the hippocampus on cortical thickness (CT) of connected areas. In 419 (223 F) participants (agemean=73 ± 8) from the Alzheimer's Disease Neuroimaging Initiative, cortical regions associated with memory (Rey Auditory Verbal Learning Test) were identified using Lasso regression. Two structural equation models (SEM), for SC and resting-state FC, were fitted including CT areas, and SC and FC to the left and right hippocampus (LHIP,RHIP). LHIP (β=-0.150,p=<.001) and RHIP (β=-0.139,p=<.001) SC predicted left temporopolar/rhinal CT; RHIP SC predicted right temporopolar/rhinal CT (β=-0.191,p=<.001). LHIP SC predicted right fusiform/parahippocampal (β=-0.104,p=.011) and intraparietal sulcus/superior parietal CT (β=0.101,p=.028). Increased RHIP FC predicted higher left inferior parietal CT (β=0.132,p=.042) while increased LHIP FC predicted lower right fusiform/parahippocampal CT (β=-0.97; p=.023). The hippocampi may be epicentres for cortical thinning through disrupted connectivity. Nanyang Technological University Submitted/Accepted version This work is supported by the Nanyang Assistant Professorship (Award no. 021080–00001) grant. Collection and sharing of the data was funded by the ADNI (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12–2–0012). 2024-07-15T06:54:12Z 2024-07-15T06:54:12Z 2024 Journal Article Billaud, C. H. A. & Yu, J. (2024). The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging. Neurobiology of Aging, 139, 82-89. https://dx.doi.org/10.1016/j.neurobiolaging.2024.04.004 0197-4580 https://hdl.handle.net/10356/178988 10.1016/j.neurobiolaging.2024.04.004 38657394 2-s2.0-85190843267 139 82 89 en Neurobiology of Aging © 2024 Elsevier Inc. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1016/j.neurobiolaging.2024.04.004. application/pdf |
| spellingShingle | Social Sciences Alzheimer’s disease Mild cognitive impairment Billaud, Charly Hugo Alexandre Yu, Junhong The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging |
| title | The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging |
| title_full | The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging |
| title_fullStr | The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging |
| title_full_unstemmed | The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging |
| title_short | The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging |
| title_sort | hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging |
| topic | Social Sciences Alzheimer’s disease Mild cognitive impairment |
| url | https://hdl.handle.net/10356/178988 |
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