Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor-ligand signaling complex

Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor-ligand signaling complex

Tumor necrosis factor (TNF) receptor 1 (TNFR1) plays a pivotal role in mediating TNF induced downstream signaling and regulating inflammatory response. Recent studies have suggested that TNFR1 activation involves conformational rearrangements of preligand assembled receptor dimers and targeting rece...

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Bibliographic Details
Main Authors: Zeng, Jialiu, Loi, Gavin Wen Zhao, Saipuljumria, Eka Norfaishanty, Duránc, Marco Antonio Romero, Silva-García, Octavio, Perez-Aguilard, Jose Manuel, Baizabal-Aguirre, Víctor M., Lo, Chih Hung
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
TNFR1 signaling
Conformational dynamics
Online Access:https://hdl.handle.net/10356/179004

Internet

https://hdl.handle.net/10356/179004

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