Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor-ligand signaling complex
Tumor necrosis factor (TNF) receptor 1 (TNFR1) plays a pivotal role in mediating TNF induced downstream signaling and regulating inflammatory response. Recent studies have suggested that TNFR1 activation involves conformational rearrangements of preligand assembled receptor dimers and targeting rece...
Main Authors: | Zeng, Jialiu, Loi, Gavin Wen Zhao, Saipuljumria, Eka Norfaishanty, Duránc, Marco Antonio Romero, Silva-García, Octavio, Perez-Aguilard, Jose Manuel, Baizabal-Aguirre, Víctor M., Lo, Chih Hung |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Journal Article |
Language: | English |
Published: |
2024
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/179004 |
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