Eosinophil-activating semiconducting polymer nanoparticles for cancer photo-immunotherapy
Eosinophils are important immune effector cells that affect T cell-mediated antitumor immunity. However, the low frequency and restrained activity of eosinophils restricted the outcome of cancer immunotherapies. We herein report an eosinophil-activating semiconducting polymer nanoparticle (SPNe) to...
| मुख्य लेखकों: | , , , , , , |
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| अन्य लेखक: | |
| स्वरूप: | Journal Article |
| भाषा: | English |
| प्रकाशित: |
2024
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| विषय: | |
| ऑनलाइन पहुंच: | https://hdl.handle.net/10356/179018 |
| _version_ | 1826123180903759872 |
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| author | Zhang, Chi Huang, Jingsheng Xu, Mengke Yu, Jie Wei, Xin He, Shasha Pu, Kanyi |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Zhang, Chi Huang, Jingsheng Xu, Mengke Yu, Jie Wei, Xin He, Shasha Pu, Kanyi |
| author_sort | Zhang, Chi |
| collection | NTU |
| description | Eosinophils are important immune effector cells that affect T cell-mediated antitumor immunity. However, the low frequency and restrained activity of eosinophils restricted the outcome of cancer immunotherapies. We herein report an eosinophil-activating semiconducting polymer nanoparticle (SPNe) to improve photodynamic tumor immunogenicity, modulate eosinophil chemotaxis, and reinvigorate T-cell immunity for activated cancer photo-immunotherapy. SPNe comprises an amphiphilic semiconducting polymer and a dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin via a 1O2-cleavable thioketal linker. Upon localized NIR photoirradiation, SPNe generates 1O2 to elicit immunogenic cell death of tumors and induce specific activation of sitagliptin. The subsequent inhibition of DPP4 increases intratumoral CCL11 levels to promote eosinophil chemotaxis and activation. SPNe-mediated photo-immunotherapy synergized with immune checkpoint blockade greatly promotes tumor infiltration and activation of both eosinophils and T cells, effectively inhibiting tumor growth and metastasis. Thus, this study presents a generic polymeric nanoplatform to modulate specific immune cells for precision cancer immunotherapy. |
| first_indexed | 2024-10-01T06:00:26Z |
| format | Journal Article |
| id | ntu-10356/179018 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:00:26Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1790182024-07-19T15:31:46Z Eosinophil-activating semiconducting polymer nanoparticles for cancer photo-immunotherapy Zhang, Chi Huang, Jingsheng Xu, Mengke Yu, Jie Wei, Xin He, Shasha Pu, Kanyi Lee Kong Chian School of Medicine (LKCMedicine) School of Chemistry, Chemical Engineering and Biotechnology Medicine, Health and Life Sciences Phototherapy Eosinophil · Eosinophils are important immune effector cells that affect T cell-mediated antitumor immunity. However, the low frequency and restrained activity of eosinophils restricted the outcome of cancer immunotherapies. We herein report an eosinophil-activating semiconducting polymer nanoparticle (SPNe) to improve photodynamic tumor immunogenicity, modulate eosinophil chemotaxis, and reinvigorate T-cell immunity for activated cancer photo-immunotherapy. SPNe comprises an amphiphilic semiconducting polymer and a dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin via a 1O2-cleavable thioketal linker. Upon localized NIR photoirradiation, SPNe generates 1O2 to elicit immunogenic cell death of tumors and induce specific activation of sitagliptin. The subsequent inhibition of DPP4 increases intratumoral CCL11 levels to promote eosinophil chemotaxis and activation. SPNe-mediated photo-immunotherapy synergized with immune checkpoint blockade greatly promotes tumor infiltration and activation of both eosinophils and T cells, effectively inhibiting tumor growth and metastasis. Thus, this study presents a generic polymeric nanoplatform to modulate specific immune cells for precision cancer immunotherapy. Ministry of Education (MOE) National Research Foundation (NRF) Submitted/Accepted version K.P. thanks Singapore National Research Foundation (NRF) (NRF-NRFI07-2021-0005) and the Singapore Minis-try of Education, Academic Research Fund Tier 2 (MOE-T2EP30220-0010; MOE-T2EP30221-0004) for the financial support. 2024-07-16T05:02:23Z 2024-07-16T05:02:23Z 2024 Journal Article Zhang, C., Huang, J., Xu, M., Yu, J., Wei, X., He, S. & Pu, K. (2024). Eosinophil-activating semiconducting polymer nanoparticles for cancer photo-immunotherapy. Angewandte Chemie International Edition, 63(30), e202405358-. https://dx.doi.org/10.1002/anie.202405358 1433-7851 https://hdl.handle.net/10356/179018 10.1002/anie.202405358 38700137 2-s2.0-85196282742 30 63 e202405358 en NRF-NRFI07-2021-0005 MOE-T2EP30220-0010 MOE-T2EP30221-0004 Angewandte Chemie International Edition © 2024 Wiley-VCH GmbH. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1002/anie.202405358. application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Phototherapy Eosinophil · Zhang, Chi Huang, Jingsheng Xu, Mengke Yu, Jie Wei, Xin He, Shasha Pu, Kanyi Eosinophil-activating semiconducting polymer nanoparticles for cancer photo-immunotherapy |
| title | Eosinophil-activating semiconducting polymer nanoparticles for cancer photo-immunotherapy |
| title_full | Eosinophil-activating semiconducting polymer nanoparticles for cancer photo-immunotherapy |
| title_fullStr | Eosinophil-activating semiconducting polymer nanoparticles for cancer photo-immunotherapy |
| title_full_unstemmed | Eosinophil-activating semiconducting polymer nanoparticles for cancer photo-immunotherapy |
| title_short | Eosinophil-activating semiconducting polymer nanoparticles for cancer photo-immunotherapy |
| title_sort | eosinophil activating semiconducting polymer nanoparticles for cancer photo immunotherapy |
| topic | Medicine, Health and Life Sciences Phototherapy Eosinophil · |
| url | https://hdl.handle.net/10356/179018 |
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