Highly flexible and controllable hierarchical MOF membrane for efficient drug release
An active wound dressing that is biomechanically and biochemically effective is essential for wound care and skin tissue regeneration. Despite its importance, issues persist with mechanical compatibility and drug release control, restricting the optimal use of existing dressings. In this work, we pr...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/179029 |
| _version_ | 1826112531619381248 |
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| author | Li, Jiaxin Yan, Yachao Fang, Qinglin Chen, Yingzhi Jing, Qihang Lee, Hiang Kwee Wang, Lu-Ning |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Li, Jiaxin Yan, Yachao Fang, Qinglin Chen, Yingzhi Jing, Qihang Lee, Hiang Kwee Wang, Lu-Ning |
| author_sort | Li, Jiaxin |
| collection | NTU |
| description | An active wound dressing that is biomechanically and biochemically effective is essential for wound care and skin tissue regeneration. Despite its importance, issues persist with mechanical compatibility and drug release control, restricting the optimal use of existing dressings. In this work, we present a simple approach using a poly (vinylidene fluoride) (PVDF) substrate containing zeolitic imidazolate framework (ZIF-8) seeds of different sizes to start the precise development of a highly flexible metal-organic framework membrane with a consistent honeycomb structure, suitable for drug loading and release. With the embedded seeds serving as a control center, the honeycomb membrane formed features pore openings ranging from 0.7 to 3 µm. These adjustable microscale pores, combined with the intrinsic nanopores in ZIF-8, facilitate efficient loading of the anti-inflammatory drug curcumin (CCM) and enable its rapid and controlled release for antibacterial activity and cell growth. Among these, the 0.7-µm honeycomb membrane produced on the 40-nm seed showed a 2-fold increase in cell proliferation compared with the honeycomb membrane (equal to the bare PVDF substrate). Furthermore, it displayed 5 and 2.4 times greater antibacterial activity against Staphylococcus aureus and Escherichia coli than the substrate. These results are attributable to the balanced influence of CCM and Zn2+ release properties from such ideal pore geometries. The controllable and hierarchical pore-arrayed membrane boasts unique characteristics that make it a promising option for wound healing. Additionally, it offers valuable insights for the design of future biomedicine applications. |
| first_indexed | 2024-10-01T03:08:34Z |
| format | Journal Article |
| id | ntu-10356/179029 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:08:34Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1790292024-07-16T07:19:44Z Highly flexible and controllable hierarchical MOF membrane for efficient drug release Li, Jiaxin Yan, Yachao Fang, Qinglin Chen, Yingzhi Jing, Qihang Lee, Hiang Kwee Wang, Lu-Ning School of Chemistry, Chemical Engineering and Biotechnology Engineering MOF membrane Hierarchical pores An active wound dressing that is biomechanically and biochemically effective is essential for wound care and skin tissue regeneration. Despite its importance, issues persist with mechanical compatibility and drug release control, restricting the optimal use of existing dressings. In this work, we present a simple approach using a poly (vinylidene fluoride) (PVDF) substrate containing zeolitic imidazolate framework (ZIF-8) seeds of different sizes to start the precise development of a highly flexible metal-organic framework membrane with a consistent honeycomb structure, suitable for drug loading and release. With the embedded seeds serving as a control center, the honeycomb membrane formed features pore openings ranging from 0.7 to 3 µm. These adjustable microscale pores, combined with the intrinsic nanopores in ZIF-8, facilitate efficient loading of the anti-inflammatory drug curcumin (CCM) and enable its rapid and controlled release for antibacterial activity and cell growth. Among these, the 0.7-µm honeycomb membrane produced on the 40-nm seed showed a 2-fold increase in cell proliferation compared with the honeycomb membrane (equal to the bare PVDF substrate). Furthermore, it displayed 5 and 2.4 times greater antibacterial activity against Staphylococcus aureus and Escherichia coli than the substrate. These results are attributable to the balanced influence of CCM and Zn2+ release properties from such ideal pore geometries. The controllable and hierarchical pore-arrayed membrane boasts unique characteristics that make it a promising option for wound healing. Additionally, it offers valuable insights for the design of future biomedicine applications. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) Nanyang Technological University This work was financially supported by the National Natural Science Foundation of China (52371248), National Key R&D Program of China (2021YFB3802200), Guangdong Basic and Applied Basic Research Foundation (2023A1515010905) and the Scientific and Technological Innovation Foundation of Shunde Graduate School, USTB (BK22BE012). Lee HK thanks the funding supports from Singapore Ministry of Education (AcRF Tier 1 RS13/20 and RG4/21), A*STAR Singapore (AME YIRG A2084c0158), the Center of Hydrogen Innovation, National University of Singapore (CHI-P2022-05), and Nanyang Technological University Startup Grants. 2024-07-16T07:19:44Z 2024-07-16T07:19:44Z 2024 Journal Article Li, J., Yan, Y., Fang, Q., Chen, Y., Jing, Q., Lee, H. K. & Wang, L. (2024). Highly flexible and controllable hierarchical MOF membrane for efficient drug release. Science China Materials, 67(5), 1509-1520. https://dx.doi.org/10.1007/s40843-024-2909-9 2199-4501 https://hdl.handle.net/10356/179029 10.1007/s40843-024-2909-9 2-s2.0-85190828055 5 67 1509 1520 en RS13/20 RG4/21 AME-YIRG-A2084c0158 CHI-P2022-05 NTU SUG Science China Materials © 2024 Science China Press. All rights reserved. |
| spellingShingle | Engineering MOF membrane Hierarchical pores Li, Jiaxin Yan, Yachao Fang, Qinglin Chen, Yingzhi Jing, Qihang Lee, Hiang Kwee Wang, Lu-Ning Highly flexible and controllable hierarchical MOF membrane for efficient drug release |
| title | Highly flexible and controllable hierarchical MOF membrane for efficient drug release |
| title_full | Highly flexible and controllable hierarchical MOF membrane for efficient drug release |
| title_fullStr | Highly flexible and controllable hierarchical MOF membrane for efficient drug release |
| title_full_unstemmed | Highly flexible and controllable hierarchical MOF membrane for efficient drug release |
| title_short | Highly flexible and controllable hierarchical MOF membrane for efficient drug release |
| title_sort | highly flexible and controllable hierarchical mof membrane for efficient drug release |
| topic | Engineering MOF membrane Hierarchical pores |
| url | https://hdl.handle.net/10356/179029 |
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