NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy
Due to the relatively low efficiency of magnetic hyperthermia and photothermal conversion, it is rather challenging for magneto-photothermal nanoagents to be used as an effective treatment during tumor hyperthermal therapy. The advancement of magnetic nanoparticles exhibiting a vortex-domain structu...
| Main Authors: | , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/179431 |
| _version_ | 1811692557548126208 |
|---|---|
| author | Shen, Kaiming Li, Lixian Tan, Funan Ang, Calvin Ching Lan Jin, Tianli Xue, Zongguo Wu, Shuo Chee, Mun Yin Yan, Yunfei Lew, Wen Siang |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Shen, Kaiming Li, Lixian Tan, Funan Ang, Calvin Ching Lan Jin, Tianli Xue, Zongguo Wu, Shuo Chee, Mun Yin Yan, Yunfei Lew, Wen Siang |
| author_sort | Shen, Kaiming |
| collection | NTU |
| description | Due to the relatively low efficiency of magnetic hyperthermia and photothermal conversion, it is rather challenging for magneto-photothermal nanoagents to be used as an effective treatment during tumor hyperthermal therapy. The advancement of magnetic nanoparticles exhibiting a vortex-domain structure holds great promise as a viable strategy to enhance the application performance of conventional magnetic nanoparticles while retaining their inherent biocompatibility. Here, we report the development of Mn0.5Zn0.5Fe2O4 nanoflowers with ellipsoidal magnetic cores, and show them as effective nanoagents for magneto-photothermal synergistic therapy. Comparative studies were conducted on the heating performance of anisometric Mn0.5Zn0.5Fe2O4 (MZF) nanoparticles, including nanocubes (MZF-C), hollow spheres (MZF-HS), nanoflowers consisting of ellipsoidal magnetic cores (MZF-NFE), and nanoflowers consisting of needle-like magnetic cores (MZF-NFN). MZF-NFE exhibits an intrinsic loss parameter (ILP) of up to 15.3 N h m2 kg-1, which is better than that of commercial equivalents. Micromagnetic simulations reveal the magnetization configurations and reversal characteristics of the various MZF shapes. Additionally, all nanostructures displayed a considerable photothermal conversion efficiency rate of more than 18%. Our results demonstrated that by combining the dual exposure of MHT and PTT for hyperthermia treatments induced by MZF-NFE, BT549, MCF-7, and 4T1 cell viability can be significantly decreased by ∼95.7% in vitro. |
| first_indexed | 2024-10-01T06:37:41Z |
| format | Journal Article |
| id | ntu-10356/179431 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:37:41Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1794312024-07-31T01:20:25Z NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy Shen, Kaiming Li, Lixian Tan, Funan Ang, Calvin Ching Lan Jin, Tianli Xue, Zongguo Wu, Shuo Chee, Mun Yin Yan, Yunfei Lew, Wen Siang School of Physical and Mathematical Sciences Physics Magnetic hyperthermia Vortex domain structures Due to the relatively low efficiency of magnetic hyperthermia and photothermal conversion, it is rather challenging for magneto-photothermal nanoagents to be used as an effective treatment during tumor hyperthermal therapy. The advancement of magnetic nanoparticles exhibiting a vortex-domain structure holds great promise as a viable strategy to enhance the application performance of conventional magnetic nanoparticles while retaining their inherent biocompatibility. Here, we report the development of Mn0.5Zn0.5Fe2O4 nanoflowers with ellipsoidal magnetic cores, and show them as effective nanoagents for magneto-photothermal synergistic therapy. Comparative studies were conducted on the heating performance of anisometric Mn0.5Zn0.5Fe2O4 (MZF) nanoparticles, including nanocubes (MZF-C), hollow spheres (MZF-HS), nanoflowers consisting of ellipsoidal magnetic cores (MZF-NFE), and nanoflowers consisting of needle-like magnetic cores (MZF-NFN). MZF-NFE exhibits an intrinsic loss parameter (ILP) of up to 15.3 N h m2 kg-1, which is better than that of commercial equivalents. Micromagnetic simulations reveal the magnetization configurations and reversal characteristics of the various MZF shapes. Additionally, all nanostructures displayed a considerable photothermal conversion efficiency rate of more than 18%. Our results demonstrated that by combining the dual exposure of MHT and PTT for hyperthermia treatments induced by MZF-NFE, BT549, MCF-7, and 4T1 cell viability can be significantly decreased by ∼95.7% in vitro. The authors gratefully acknowledge financial support from the Fundamental Research Funds for the Central Universities (2019CDYGYB022), and the Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0448). This study was also supported by the projects of the Chongqing Clinical Pharmacy Key Specialties Construction Project and the Young and Middle-aged Leading Medical Talents of the Chongqing Health Commission. 2024-07-31T01:20:24Z 2024-07-31T01:20:24Z 2024 Journal Article Shen, K., Li, L., Tan, F., Ang, C. C. L., Jin, T., Xue, Z., Wu, S., Chee, M. Y., Yan, Y. & Lew, W. S. (2024). NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy. Nanoscale, 16(21), 10428-10440. https://dx.doi.org/10.1039/d4nr00104d 2040-3364 https://hdl.handle.net/10356/179431 10.1039/d4nr00104d 38742446 2-s2.0-85193513695 21 16 10428 10440 en Nanoscale © The Author(s). All rights reserved. |
| spellingShingle | Physics Magnetic hyperthermia Vortex domain structures Shen, Kaiming Li, Lixian Tan, Funan Ang, Calvin Ching Lan Jin, Tianli Xue, Zongguo Wu, Shuo Chee, Mun Yin Yan, Yunfei Lew, Wen Siang NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy |
| title | NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy |
| title_full | NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy |
| title_fullStr | NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy |
| title_full_unstemmed | NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy |
| title_short | NIR and magnetism dual-response multi-core magnetic vortex nanoflowers for boosting magneto-photothermal cancer therapy |
| title_sort | nir and magnetism dual response multi core magnetic vortex nanoflowers for boosting magneto photothermal cancer therapy |
| topic | Physics Magnetic hyperthermia Vortex domain structures |
| url | https://hdl.handle.net/10356/179431 |
| work_keys_str_mv | AT shenkaiming nirandmagnetismdualresponsemulticoremagneticvortexnanoflowersforboostingmagnetophotothermalcancertherapy AT lilixian nirandmagnetismdualresponsemulticoremagneticvortexnanoflowersforboostingmagnetophotothermalcancertherapy AT tanfunan nirandmagnetismdualresponsemulticoremagneticvortexnanoflowersforboostingmagnetophotothermalcancertherapy AT angcalvinchinglan nirandmagnetismdualresponsemulticoremagneticvortexnanoflowersforboostingmagnetophotothermalcancertherapy AT jintianli nirandmagnetismdualresponsemulticoremagneticvortexnanoflowersforboostingmagnetophotothermalcancertherapy AT xuezongguo nirandmagnetismdualresponsemulticoremagneticvortexnanoflowersforboostingmagnetophotothermalcancertherapy AT wushuo nirandmagnetismdualresponsemulticoremagneticvortexnanoflowersforboostingmagnetophotothermalcancertherapy AT cheemunyin nirandmagnetismdualresponsemulticoremagneticvortexnanoflowersforboostingmagnetophotothermalcancertherapy AT yanyunfei nirandmagnetismdualresponsemulticoremagneticvortexnanoflowersforboostingmagnetophotothermalcancertherapy AT lewwensiang nirandmagnetismdualresponsemulticoremagneticvortexnanoflowersforboostingmagnetophotothermalcancertherapy |