A network pharmacology approach to unraveling the therapeutic effects of Huang Qi
Huang Qi (Astragalus Radix) is a TCM herb widely used to replenish ‘Qi’ in the human body. It has many properties including anti-inflammatory and anti-oxidant but the mechanisms of these properties are still unclear. As TCM evolves, it is important to integrate it into modern medicine with scientifi...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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Nanyang Technological University
2024
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| Online Access: | https://hdl.handle.net/10356/179526 |
| _version_ | 1826122098295177216 |
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| author | Lam, Xi Qi |
| author2 | Mu Yuguang |
| author_facet | Mu Yuguang Lam, Xi Qi |
| author_sort | Lam, Xi Qi |
| collection | NTU |
| description | Huang Qi (Astragalus Radix) is a TCM herb widely used to replenish ‘Qi’ in the human body. It has many properties including anti-inflammatory and anti-oxidant but the mechanisms of these properties are still unclear. As TCM evolves, it is important to integrate it into modern medicine with scientific evidence supporting its functions. Network pharmacology is a new research method for analysing complicated interactions between many compounds, making it a suitable approach in attempting to understand and identify mechanism pathways of Huang Qi. BIND software was used to conduct the molecular docking on bioactive compounds and human protein. Results were arranged according to binding affinity before splitting the data into two sets. First is the top 5000 entries, second is the top entry from each bioactive compound. Both datasets underwent KEGG, GO and Jensen DISEASE enrichment analysis and a network was generated using the top entries data. From the results, Huang Qi is suggested to be important in maintaining immune balance. It can promote immune response and be anti-inflammatory mainly due to its bidirectional regulation of cytokine. Future studies can aim to explore this topic more and even conduct the same experiment on other TCM herbs. |
| first_indexed | 2024-10-01T05:42:57Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/179526 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:42:57Z |
| publishDate | 2024 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1795262024-08-12T15:33:01Z A network pharmacology approach to unraveling the therapeutic effects of Huang Qi Lam, Xi Qi Mu Yuguang School of Biological Sciences YGMu@ntu.edu.sg Computer and Information Science Medicine, Health and Life Sciences Network pharmacology Huang Qi Huang Qi (Astragalus Radix) is a TCM herb widely used to replenish ‘Qi’ in the human body. It has many properties including anti-inflammatory and anti-oxidant but the mechanisms of these properties are still unclear. As TCM evolves, it is important to integrate it into modern medicine with scientific evidence supporting its functions. Network pharmacology is a new research method for analysing complicated interactions between many compounds, making it a suitable approach in attempting to understand and identify mechanism pathways of Huang Qi. BIND software was used to conduct the molecular docking on bioactive compounds and human protein. Results were arranged according to binding affinity before splitting the data into two sets. First is the top 5000 entries, second is the top entry from each bioactive compound. Both datasets underwent KEGG, GO and Jensen DISEASE enrichment analysis and a network was generated using the top entries data. From the results, Huang Qi is suggested to be important in maintaining immune balance. It can promote immune response and be anti-inflammatory mainly due to its bidirectional regulation of cytokine. Future studies can aim to explore this topic more and even conduct the same experiment on other TCM herbs. Bachelor's degree 2024-08-07T01:25:57Z 2024-08-07T01:25:57Z 2024 Final Year Project (FYP) Lam, X. Q. (2024). A network pharmacology approach to unraveling the therapeutic effects of Huang Qi. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/179526 https://hdl.handle.net/10356/179526 en application/pdf Nanyang Technological University |
| spellingShingle | Computer and Information Science Medicine, Health and Life Sciences Network pharmacology Huang Qi Lam, Xi Qi A network pharmacology approach to unraveling the therapeutic effects of Huang Qi |
| title | A network pharmacology approach to unraveling the therapeutic effects of Huang Qi |
| title_full | A network pharmacology approach to unraveling the therapeutic effects of Huang Qi |
| title_fullStr | A network pharmacology approach to unraveling the therapeutic effects of Huang Qi |
| title_full_unstemmed | A network pharmacology approach to unraveling the therapeutic effects of Huang Qi |
| title_short | A network pharmacology approach to unraveling the therapeutic effects of Huang Qi |
| title_sort | network pharmacology approach to unraveling the therapeutic effects of huang qi |
| topic | Computer and Information Science Medicine, Health and Life Sciences Network pharmacology Huang Qi |
| url | https://hdl.handle.net/10356/179526 |
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