Prefrontal tDCS modulates risk-taking in male violent offenders
Detrimental decision-making is a major problem among violent offenders. Non-invasive brain stimulation offers a promising method to directly influence decision-making and has already been shown to modulate risk-taking in non-violent controls. We hypothesize that anodal transcranial direct current st...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/10356/179583 |
| _version_ | 1811684130179514368 |
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| author | Kuhn, Leandra Choy, Olivia Keller, Lara Habel, Ute Wagels, Lisa |
| author2 | School of Social Sciences |
| author_facet | School of Social Sciences Kuhn, Leandra Choy, Olivia Keller, Lara Habel, Ute Wagels, Lisa |
| author_sort | Kuhn, Leandra |
| collection | NTU |
| description | Detrimental decision-making is a major problem among violent offenders. Non-invasive brain stimulation offers a promising method to directly influence decision-making and has already been shown to modulate risk-taking in non-violent controls. We hypothesize that anodal transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex beneficially modulates the neural and behavioral correlates of risk-taking in a sample of violent offenders. We expect offenders to show more risky decision-making than non-violent controls and that prefrontal tDCS will induce stronger changes in the offender group. In the current study, 22 male violent offenders and 24 male non-violent controls took part in a randomized double-blind sham-controlled cross-over study applying tDCS over the right dorsolateral prefrontal cortex. Subsequently, participants performed the Balloon Analogue Risk Task (BART) during functional magnetic resonance imaging (fMRI). Violent offenders showed significantly less optimal decision-making compared to non-violent controls. Active tDCS increased prefrontal activity and improved decision-making only in violent offenders but not in the control group. Also, in offenders only, prefrontal tDCS influenced functional connectivity between the stimulated area and other brain regions such as the thalamus. These results suggest baseline dependent effects of tDCS and pave the way for treatment options of disadvantageous decision-making behavior in this population. |
| first_indexed | 2024-10-01T04:23:44Z |
| format | Journal Article |
| id | ntu-10356/179583 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:23:44Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1795832024-08-18T15:30:25Z Prefrontal tDCS modulates risk-taking in male violent offenders Kuhn, Leandra Choy, Olivia Keller, Lara Habel, Ute Wagels, Lisa School of Social Sciences Social Sciences Prefrontal cortex Violent offenders Detrimental decision-making is a major problem among violent offenders. Non-invasive brain stimulation offers a promising method to directly influence decision-making and has already been shown to modulate risk-taking in non-violent controls. We hypothesize that anodal transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex beneficially modulates the neural and behavioral correlates of risk-taking in a sample of violent offenders. We expect offenders to show more risky decision-making than non-violent controls and that prefrontal tDCS will induce stronger changes in the offender group. In the current study, 22 male violent offenders and 24 male non-violent controls took part in a randomized double-blind sham-controlled cross-over study applying tDCS over the right dorsolateral prefrontal cortex. Subsequently, participants performed the Balloon Analogue Risk Task (BART) during functional magnetic resonance imaging (fMRI). Violent offenders showed significantly less optimal decision-making compared to non-violent controls. Active tDCS increased prefrontal activity and improved decision-making only in violent offenders but not in the control group. Also, in offenders only, prefrontal tDCS influenced functional connectivity between the stimulated area and other brain regions such as the thalamus. These results suggest baseline dependent effects of tDCS and pave the way for treatment options of disadvantageous decision-making behavior in this population. Published version This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—269953372/GRK2150. Open Access funding enabled and organized by Projekt DEAL. 2024-08-12T02:51:33Z 2024-08-12T02:51:33Z 2024 Journal Article Kuhn, L., Choy, O., Keller, L., Habel, U. & Wagels, L. (2024). Prefrontal tDCS modulates risk-taking in male violent offenders. Scientific Reports, 14(1), 10087-. https://dx.doi.org/10.1038/s41598-024-60795-z 2045-2322 https://hdl.handle.net/10356/179583 10.1038/s41598-024-60795-z 38698192 2-s2.0-85191991189 1 14 10087 en Scientific Reports © 2024 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. application/pdf |
| spellingShingle | Social Sciences Prefrontal cortex Violent offenders Kuhn, Leandra Choy, Olivia Keller, Lara Habel, Ute Wagels, Lisa Prefrontal tDCS modulates risk-taking in male violent offenders |
| title | Prefrontal tDCS modulates risk-taking in male violent offenders |
| title_full | Prefrontal tDCS modulates risk-taking in male violent offenders |
| title_fullStr | Prefrontal tDCS modulates risk-taking in male violent offenders |
| title_full_unstemmed | Prefrontal tDCS modulates risk-taking in male violent offenders |
| title_short | Prefrontal tDCS modulates risk-taking in male violent offenders |
| title_sort | prefrontal tdcs modulates risk taking in male violent offenders |
| topic | Social Sciences Prefrontal cortex Violent offenders |
| url | https://hdl.handle.net/10356/179583 |
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