Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening
Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening. By employing diverse types of spheroids or organoids, it is feasible to establish microphysiological systems that enhance the precision of disease modeling and offer more depend...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/179633 |
| _version_ | 1811679299177021440 |
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| author | Zhu, Yuxuan Jiang, Deming Qiu, Yong Liu, Xin Bian, Yuhan Tian, Shichao Wang, Xiandi Hsia, K. Jimmy Wan, Hao Zhuang, Liujing Wang, Ping |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Zhu, Yuxuan Jiang, Deming Qiu, Yong Liu, Xin Bian, Yuhan Tian, Shichao Wang, Xiandi Hsia, K. Jimmy Wan, Hao Zhuang, Liujing Wang, Ping |
| author_sort | Zhu, Yuxuan |
| collection | NTU |
| description | Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening. By employing diverse types of spheroids or organoids, it is feasible to establish microphysiological systems that enhance the precision of disease modeling and offer more dependable and comprehensive drug screening. High-throughput microphysiological systems that support optional, parallel testing of multiple drugs have promising applications in personalized medical treatment and drug research. However, establishing such a system is highly challenging and requires a multidisciplinary approach. This study introduces a dynamic Microphysiological System Chip Platform (MSCP) with multiple functional microstructures that encompass the mentioned advantages. We developed a high-throughput lung cancer spheroids model and an intestine-liver-heart-lung cancer microphysiological system for conducting parallel testing on four anti-lung cancer drugs, demonstrating the feasibility of the MSCP. This microphysiological system combines microscale and macroscale biomimetics to enable a comprehensive assessment of drug efficacy and side effects. Moreover, the microphysiological system enables evaluation of the real pharmacological effect of drug molecules reaching the target lesion after absorption by normal organs through fluid-based physiological communication. The MSCP could serves as a valuable platform for microphysiological system research, making significant contributions to disease modeling, drug development, and personalized medical treatment. |
| first_indexed | 2024-10-01T03:06:57Z |
| format | Journal Article |
| id | ntu-10356/179633 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:06:57Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1796332024-08-17T16:48:22Z Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening Zhu, Yuxuan Jiang, Deming Qiu, Yong Liu, Xin Bian, Yuhan Tian, Shichao Wang, Xiandi Hsia, K. Jimmy Wan, Hao Zhuang, Liujing Wang, Ping School of Mechanical and Aerospace Engineering School of Chemical and Biomedical Engineering Engineering Microphysiological system Biomimetics Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening. By employing diverse types of spheroids or organoids, it is feasible to establish microphysiological systems that enhance the precision of disease modeling and offer more dependable and comprehensive drug screening. High-throughput microphysiological systems that support optional, parallel testing of multiple drugs have promising applications in personalized medical treatment and drug research. However, establishing such a system is highly challenging and requires a multidisciplinary approach. This study introduces a dynamic Microphysiological System Chip Platform (MSCP) with multiple functional microstructures that encompass the mentioned advantages. We developed a high-throughput lung cancer spheroids model and an intestine-liver-heart-lung cancer microphysiological system for conducting parallel testing on four anti-lung cancer drugs, demonstrating the feasibility of the MSCP. This microphysiological system combines microscale and macroscale biomimetics to enable a comprehensive assessment of drug efficacy and side effects. Moreover, the microphysiological system enables evaluation of the real pharmacological effect of drug molecules reaching the target lesion after absorption by normal organs through fluid-based physiological communication. The MSCP could serves as a valuable platform for microphysiological system research, making significant contributions to disease modeling, drug development, and personalized medical treatment. Published version This research was funded by the National Key Research and Development Program of China (No. 2021YFF1200803); National Natural Science Foundation of China (No. 62120106004, 61901412, 62271443); and China Postdoctoral Science Foundation Funded Project (2022M712783). 2024-08-13T07:53:08Z 2024-08-13T07:53:08Z 2024 Journal Article Zhu, Y., Jiang, D., Qiu, Y., Liu, X., Bian, Y., Tian, S., Wang, X., Hsia, K. J., Wan, H., Zhuang, L. & Wang, P. (2024). Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening. Bioactive Materials, 39, 59-73. https://dx.doi.org/10.1016/j.bioactmat.2024.05.019 2452-199X https://hdl.handle.net/10356/179633 10.1016/j.bioactmat.2024.05.019 2-s2.0-85193288573 39 59 73 en Bioactive Materials © 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). application/pdf |
| spellingShingle | Engineering Microphysiological system Biomimetics Zhu, Yuxuan Jiang, Deming Qiu, Yong Liu, Xin Bian, Yuhan Tian, Shichao Wang, Xiandi Hsia, K. Jimmy Wan, Hao Zhuang, Liujing Wang, Ping Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening |
| title | Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening |
| title_full | Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening |
| title_fullStr | Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening |
| title_full_unstemmed | Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening |
| title_short | Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening |
| title_sort | dynamic microphysiological system chip platform for high throughput customizable and multi dimensional drug screening |
| topic | Engineering Microphysiological system Biomimetics |
| url | https://hdl.handle.net/10356/179633 |
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