Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver

Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver

ADAR1-mediated RNA editing establishes immune tolerance to endogenous double-stranded RNA (dsRNA) by preventing its sensing, primarily by MDA5. Although deleting Ifih1 (encoding MDA5) rescues embryonic lethality in ADAR1-deficient mice, they still experience early postnatal death, and removing other...

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Bibliographic Details
Main Authors: Gan, Wei Liang, Ren, Xi, Ng, Vanessa Hui En, Ng, Larry, Song, Yangyang, Tano, Vincent, Han, Jian, An, Omer, Xie, Jinghe, Ng, Bryan Y. L., Tay, Daryl Jin Tai, Tang, Sze Jing, Shen, Haoqing, Khare, Shruti, Chong, Kelvin Han Chung, Young, Dan Yock, Wu, Bin, DasGupta, Ramanuj, Chen, Leilei
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Immunosuppression
Liver inflammation
Online Access:https://hdl.handle.net/10356/179659

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