Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells
Proinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components. Here, we investigate whether cytokines regulate NMD activity and identify transc...
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Bibliographic Details
| Main Authors: |
Ghiasi, Seyed M.,
Marchetti, Piero,
Piemonti, Lorenzo,
Nielsen, Jens H.,
Porse, Bo T.,
Mandrup-Poulsen, Thomas,
Rutter, Guy A. |
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| Other Authors: |
Lee Kong Chian School of Medicine (LKCMedicine) |
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| Format: | Journal Article
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| Language: | English |
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| Published: |
2024
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| Subjects: | |
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| Online Access: | https://hdl.handle.net/10356/179681
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