Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis

Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis

Objective: Type 2 diabetes (T2D) is characterised by the loss of first-phase insulin secretion. We studied mice with β-cell selective loss of the glucagon receptor (Gcgrfl/fl X Ins-1Cre), to investigate the role of intra-islet glucagon receptor (GCGR) signalling on pan-islet [Ca2+]I activity and ins...

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Bibliographic Details
Main Authors: Suba, K., Patel, Y., Martin-Alonso, A., Hansen, B., Xu, X., Roberts, A., Norton, M., Chung, P., Shrewsbury, J., Kwok, R., Kalogianni, V., Chen, S., Liu, X., Kalyviotis, K., Rutter, Guy A., Jones, B., Minnion, J., Owen, B. M., Pantazis, P., Distaso, W., Drucker, D. J., Tan, T. M., Bloom, S. R., Murphy, K. G., Salem, V.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Calcium waves
Glucagon
Online Access:https://hdl.handle.net/10356/179717

Internet

https://hdl.handle.net/10356/179717

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