Bilateral pattern electroretinogram abnormalities in patients with herpes zoster keratitis and conjunctivitis
Introduction: Herpes zoster ophthalmicus (HZO) results from the reactivation of varicella zoster virus (VZV) in the ophthalmic branch of the trigeminal nerve. The inflammation caused by VZV involves multiple tissues in the eyes. Our goal is to evaluate pattern electroretinogram (PERG) changes and th...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/179744 |
| _version_ | 1826116209317249024 |
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| author | Li, Jingyi Wang, Yuexin Xie, Xin Zeng, Weizhen Li, Shiying Agrawal, Rupesh Feng, Yun |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Li, Jingyi Wang, Yuexin Xie, Xin Zeng, Weizhen Li, Shiying Agrawal, Rupesh Feng, Yun |
| author_sort | Li, Jingyi |
| collection | NTU |
| description | Introduction: Herpes zoster ophthalmicus (HZO) results from the reactivation of varicella zoster virus (VZV) in the ophthalmic branch of the trigeminal nerve. The inflammation caused by VZV involves multiple tissues in the eyes. Our goal is to evaluate pattern electroretinogram (PERG) changes and their relationship with corneal sub-basal nerve changes in patients with HZO. Methods: Twenty-two patients with herpes zoster keratitis or conjunctivitis and 20 healthy volunteers were recruited for this cross-sectional study. A PERG test was performed on both eyes of HZO patients and one eye of the healthy controls. In vivo confocal microscopy (IVCM) was also performed on both eyes of the HZO patients to detect corneal nerve damage. Results: Our results showed changes in the PERG parameters in both eyes of HZO patients compared to the healthy controls. Affected eyes showed delayed N95 peak time and decreased P50 and N95 amplitude compared to the unaffected eyes (p < 0.05, respectively). Both affected and unaffected eyes in HZO patients showed delayed P50 peak time and decreased N95 amplitude (p < 0.05, respectively) compared to controls. In HZO patients, no significant differences in each PERG parameter were found between eyes with and without corneal lesions or between eyes with and without increased Langham’s cells in the corneal epithelial sub-basal layer. The IVCM images showed decreased total nerve length and number at the sub-basal layer of the epithelial cornea in affected eyes compared to unaffected eyes (p < 0.05). No significant correlation was found between total nerve length and PERG changes. Conclusions: Our results showed that VZV-affected eyes without central cornea involvement displayed reduced N95 amplitude and prolonged P50 peak time in bilateral eyes compared to the healthy controls. Larger studies are needed to further explore the effect of HZO on the electrophysiological response of the eye and the posterior segment. |
| first_indexed | 2024-10-01T04:07:35Z |
| format | Journal Article |
| id | ntu-10356/179744 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:07:35Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1797442024-08-25T15:38:14Z Bilateral pattern electroretinogram abnormalities in patients with herpes zoster keratitis and conjunctivitis Li, Jingyi Wang, Yuexin Xie, Xin Zeng, Weizhen Li, Shiying Agrawal, Rupesh Feng, Yun Lee Kong Chian School of Medicine (LKCMedicine) National Healthcare Group Eye Institute Singapore Eye Research Institute Medicine, Health and Life Sciences Herpes zoster ophthalmicus Pattern electroretinogram Introduction: Herpes zoster ophthalmicus (HZO) results from the reactivation of varicella zoster virus (VZV) in the ophthalmic branch of the trigeminal nerve. The inflammation caused by VZV involves multiple tissues in the eyes. Our goal is to evaluate pattern electroretinogram (PERG) changes and their relationship with corneal sub-basal nerve changes in patients with HZO. Methods: Twenty-two patients with herpes zoster keratitis or conjunctivitis and 20 healthy volunteers were recruited for this cross-sectional study. A PERG test was performed on both eyes of HZO patients and one eye of the healthy controls. In vivo confocal microscopy (IVCM) was also performed on both eyes of the HZO patients to detect corneal nerve damage. Results: Our results showed changes in the PERG parameters in both eyes of HZO patients compared to the healthy controls. Affected eyes showed delayed N95 peak time and decreased P50 and N95 amplitude compared to the unaffected eyes (p < 0.05, respectively). Both affected and unaffected eyes in HZO patients showed delayed P50 peak time and decreased N95 amplitude (p < 0.05, respectively) compared to controls. In HZO patients, no significant differences in each PERG parameter were found between eyes with and without corneal lesions or between eyes with and without increased Langham’s cells in the corneal epithelial sub-basal layer. The IVCM images showed decreased total nerve length and number at the sub-basal layer of the epithelial cornea in affected eyes compared to unaffected eyes (p < 0.05). No significant correlation was found between total nerve length and PERG changes. Conclusions: Our results showed that VZV-affected eyes without central cornea involvement displayed reduced N95 amplitude and prolonged P50 peak time in bilateral eyes compared to the healthy controls. Larger studies are needed to further explore the effect of HZO on the electrophysiological response of the eye and the posterior segment. Published version This study was supported by National Natural Science Foundation of China Grants (No. 81700799; 82070926). The authors funded the journal’s Rapid Service Fee. 2024-08-20T05:40:08Z 2024-08-20T05:40:08Z 2024 Journal Article Li, J., Wang, Y., Xie, X., Zeng, W., Li, S., Agrawal, R. & Feng, Y. (2024). Bilateral pattern electroretinogram abnormalities in patients with herpes zoster keratitis and conjunctivitis. Ophthalmology and Therapy, 13(6), 1589-1599. https://dx.doi.org/10.1007/s40123-024-00928-9 2193-8245 https://hdl.handle.net/10356/179744 10.1007/s40123-024-00928-9 38587772 2-s2.0-85189664411 6 13 1589 1599 en Ophthalmology and Therapy © 2024 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons.org/licenses/by-nc/4.0/. application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Herpes zoster ophthalmicus Pattern electroretinogram Li, Jingyi Wang, Yuexin Xie, Xin Zeng, Weizhen Li, Shiying Agrawal, Rupesh Feng, Yun Bilateral pattern electroretinogram abnormalities in patients with herpes zoster keratitis and conjunctivitis |
| title | Bilateral pattern electroretinogram abnormalities in patients with herpes zoster keratitis and conjunctivitis |
| title_full | Bilateral pattern electroretinogram abnormalities in patients with herpes zoster keratitis and conjunctivitis |
| title_fullStr | Bilateral pattern electroretinogram abnormalities in patients with herpes zoster keratitis and conjunctivitis |
| title_full_unstemmed | Bilateral pattern electroretinogram abnormalities in patients with herpes zoster keratitis and conjunctivitis |
| title_short | Bilateral pattern electroretinogram abnormalities in patients with herpes zoster keratitis and conjunctivitis |
| title_sort | bilateral pattern electroretinogram abnormalities in patients with herpes zoster keratitis and conjunctivitis |
| topic | Medicine, Health and Life Sciences Herpes zoster ophthalmicus Pattern electroretinogram |
| url | https://hdl.handle.net/10356/179744 |
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