Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation

Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation

Seipin is one key mediator of lipid metabolism that is highly expressed in adipose tissues as well as in the brain. Lack of Seipin gene, Bscl2, leads to not only severe lipid metabolic disorders but also cognitive impairments and motor disabilities. Myelin, composed mainly of lipids, facilitates ner...

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Bibliographic Details
Main Authors: Cui, Wenli, Yang, Jing, Tu, Chuanyun, Zhang, Ziting, Zhao, Huifang, Qiao, Yan, Li, Yanqiu, Yang, Wulin, Lim, Kah-Leong, Ma, Quanhong, Zhang, Chengwu, Lu, Li
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Seipin
Lipid dysregulation
Online Access:https://hdl.handle.net/10356/179802

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