Epidemiology, clinical, and microbiological characteristics of multidrug-resistant gram-negative bacteremia in Qatar
Antimicrobial resistance is a global healthcare threat with significant clinical and economic consequences peaking at secondary and tertiary care hospitals where multidrug-resistant Gram-negative bacteria (MDR GNB) lead to poor outcomes. A prospective study was conducted between January and December...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/179831 |
| _version_ | 1811696608847331328 |
|---|---|
| author | Hadi, Hamad Abdel Dargham, Soha R. Eltayeb, Faiha Ali, Mohamed O. K. Suliman, Jinan Ahmed, Shiema Abdalla M. Omrani, Ali S. Ibrahim, Emad Bashir Chen, Yuzhou Tsui, Clement Kin-Ming Skariah, Sini Sultan, Ali |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Hadi, Hamad Abdel Dargham, Soha R. Eltayeb, Faiha Ali, Mohamed O. K. Suliman, Jinan Ahmed, Shiema Abdalla M. Omrani, Ali S. Ibrahim, Emad Bashir Chen, Yuzhou Tsui, Clement Kin-Ming Skariah, Sini Sultan, Ali |
| author_sort | Hadi, Hamad Abdel |
| collection | NTU |
| description | Antimicrobial resistance is a global healthcare threat with significant clinical and economic consequences peaking at secondary and tertiary care hospitals where multidrug-resistant Gram-negative bacteria (MDR GNB) lead to poor outcomes. A prospective study was conducted between January and December 2019 for all invasive bloodstream infections (BSIs) secondary to MDR GNB in Qatar identified during routine microbiological service to examine their clinical, microbiological, and genomic characteristics. Out of 3238 episodes of GNB BSIs, the prevalence of MDR GNB was 13% (429/3238). The predominant MDR pathogens were Escherichia coli (62.7%), Klebsiella pneumoniae (20.4%), Salmonella species (6.6%), and Pseudomonas aeruginosa (5.3%), while out of 245 clinically evaluated patients, the majority were adult males, with the elderly constituting almost one-third of the cohort and with highest observed risk for prolonged hospital stays. The risk factors identified included multiple comorbidities, recent healthcare contact, previous antimicrobial therapy, and admission to critical care. The in-hospital mortality rate was recorded at 25.7%, associated with multiple comorbidities, admission to critical care, and the acquisition of MDR Pseudomonas aeruginosa. Resistant pathogens demonstrated high levels of antimicrobial resistance but noticeable susceptibility to amikacin and carbapenems. Genomic analysis revealed that Escherichia coli ST131 and Salmonella enterica ST1 were the predominant clones not observed with other pathogens. |
| first_indexed | 2024-10-01T07:42:04Z |
| format | Journal Article |
| id | ntu-10356/179831 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:42:04Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1798312024-09-01T15:38:12Z Epidemiology, clinical, and microbiological characteristics of multidrug-resistant gram-negative bacteremia in Qatar Hadi, Hamad Abdel Dargham, Soha R. Eltayeb, Faiha Ali, Mohamed O. K. Suliman, Jinan Ahmed, Shiema Abdalla M. Omrani, Ali S. Ibrahim, Emad Bashir Chen, Yuzhou Tsui, Clement Kin-Ming Skariah, Sini Sultan, Ali Lee Kong Chian School of Medicine (LKCMedicine) National Centre for Infectious Diseases, Singapore Medicine, Health and Life Sciences Antimicrobial resistance Gram-negative bacteria Antimicrobial resistance is a global healthcare threat with significant clinical and economic consequences peaking at secondary and tertiary care hospitals where multidrug-resistant Gram-negative bacteria (MDR GNB) lead to poor outcomes. A prospective study was conducted between January and December 2019 for all invasive bloodstream infections (BSIs) secondary to MDR GNB in Qatar identified during routine microbiological service to examine their clinical, microbiological, and genomic characteristics. Out of 3238 episodes of GNB BSIs, the prevalence of MDR GNB was 13% (429/3238). The predominant MDR pathogens were Escherichia coli (62.7%), Klebsiella pneumoniae (20.4%), Salmonella species (6.6%), and Pseudomonas aeruginosa (5.3%), while out of 245 clinically evaluated patients, the majority were adult males, with the elderly constituting almost one-third of the cohort and with highest observed risk for prolonged hospital stays. The risk factors identified included multiple comorbidities, recent healthcare contact, previous antimicrobial therapy, and admission to critical care. The in-hospital mortality rate was recorded at 25.7%, associated with multiple comorbidities, admission to critical care, and the acquisition of MDR Pseudomonas aeruginosa. Resistant pathogens demonstrated high levels of antimicrobial resistance but noticeable susceptibility to amikacin and carbapenems. Genomic analysis revealed that Escherichia coli ST131 and Salmonella enterica ST1 were the predominant clones not observed with other pathogens. Published version This publication was made possible by an NPRP grant (NPRP12S-0219-190109) from the Qatar National Research Fund (a member of Qatar Foundation). The submitted findings achieved herein are solely the responsibility of the author(s). 2024-08-27T01:15:37Z 2024-08-27T01:15:37Z 2024 Journal Article Hadi, H. A., Dargham, S. R., Eltayeb, F., Ali, M. O. K., Suliman, J., Ahmed, S. A. M., Omrani, A. S., Ibrahim, E. B., Chen, Y., Tsui, C. K., Skariah, S. & Sultan, A. (2024). Epidemiology, clinical, and microbiological characteristics of multidrug-resistant gram-negative bacteremia in Qatar. Antibiotics, 13(4), 320-. https://dx.doi.org/10.3390/antibiotics13040320 2079-6382 https://hdl.handle.net/10356/179831 10.3390/antibiotics13040320 38666996 2-s2.0-85191579233 4 13 320 en Antibiotics © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Antimicrobial resistance Gram-negative bacteria Hadi, Hamad Abdel Dargham, Soha R. Eltayeb, Faiha Ali, Mohamed O. K. Suliman, Jinan Ahmed, Shiema Abdalla M. Omrani, Ali S. Ibrahim, Emad Bashir Chen, Yuzhou Tsui, Clement Kin-Ming Skariah, Sini Sultan, Ali Epidemiology, clinical, and microbiological characteristics of multidrug-resistant gram-negative bacteremia in Qatar |
| title | Epidemiology, clinical, and microbiological characteristics of multidrug-resistant gram-negative bacteremia in Qatar |
| title_full | Epidemiology, clinical, and microbiological characteristics of multidrug-resistant gram-negative bacteremia in Qatar |
| title_fullStr | Epidemiology, clinical, and microbiological characteristics of multidrug-resistant gram-negative bacteremia in Qatar |
| title_full_unstemmed | Epidemiology, clinical, and microbiological characteristics of multidrug-resistant gram-negative bacteremia in Qatar |
| title_short | Epidemiology, clinical, and microbiological characteristics of multidrug-resistant gram-negative bacteremia in Qatar |
| title_sort | epidemiology clinical and microbiological characteristics of multidrug resistant gram negative bacteremia in qatar |
| topic | Medicine, Health and Life Sciences Antimicrobial resistance Gram-negative bacteria |
| url | https://hdl.handle.net/10356/179831 |
| work_keys_str_mv | AT hadihamadabdel epidemiologyclinicalandmicrobiologicalcharacteristicsofmultidrugresistantgramnegativebacteremiainqatar AT darghamsohar epidemiologyclinicalandmicrobiologicalcharacteristicsofmultidrugresistantgramnegativebacteremiainqatar AT eltayebfaiha epidemiologyclinicalandmicrobiologicalcharacteristicsofmultidrugresistantgramnegativebacteremiainqatar AT alimohamedok epidemiologyclinicalandmicrobiologicalcharacteristicsofmultidrugresistantgramnegativebacteremiainqatar AT sulimanjinan epidemiologyclinicalandmicrobiologicalcharacteristicsofmultidrugresistantgramnegativebacteremiainqatar AT ahmedshiemaabdallam epidemiologyclinicalandmicrobiologicalcharacteristicsofmultidrugresistantgramnegativebacteremiainqatar AT omranialis epidemiologyclinicalandmicrobiologicalcharacteristicsofmultidrugresistantgramnegativebacteremiainqatar AT ibrahimemadbashir epidemiologyclinicalandmicrobiologicalcharacteristicsofmultidrugresistantgramnegativebacteremiainqatar AT chenyuzhou epidemiologyclinicalandmicrobiologicalcharacteristicsofmultidrugresistantgramnegativebacteremiainqatar AT tsuiclementkinming epidemiologyclinicalandmicrobiologicalcharacteristicsofmultidrugresistantgramnegativebacteremiainqatar AT skariahsini epidemiologyclinicalandmicrobiologicalcharacteristicsofmultidrugresistantgramnegativebacteremiainqatar AT sultanali epidemiologyclinicalandmicrobiologicalcharacteristicsofmultidrugresistantgramnegativebacteremiainqatar |