Modelling the dynamics of microbubble undergoing stable and inertial cavitation: delineating the effects of ultrasound and microbubble parameters on sonothrombolysis

Sonothrombolysis induces clot breakdown using ultrasound waves to excite microbubbles. Despite the great potential, selecting optimal ultrasound (frequency and pressure) and microbubble (radius) parameters remains a challenge. To address this, a computational model was developed to investigate the b...

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Main Authors: Tan, Zhi Qi, Ooi, Ean Hin, Chiew, Yeong Shiong, Foo, Ji Jinn, Ng, Yin Kwee, Ooi, Ean Tat
Other Authors: School of Mechanical and Aerospace Engineering
Format: Journal Article
Language:English
Published: 2024
Subjects:
Online Access:https://hdl.handle.net/10356/180064
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author Tan, Zhi Qi
Ooi, Ean Hin
Chiew, Yeong Shiong
Foo, Ji Jinn
Ng, Yin Kwee
Ooi, Ean Tat
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Tan, Zhi Qi
Ooi, Ean Hin
Chiew, Yeong Shiong
Foo, Ji Jinn
Ng, Yin Kwee
Ooi, Ean Tat
author_sort Tan, Zhi Qi
collection NTU
description Sonothrombolysis induces clot breakdown using ultrasound waves to excite microbubbles. Despite the great potential, selecting optimal ultrasound (frequency and pressure) and microbubble (radius) parameters remains a challenge. To address this, a computational model was developed to investigate the bubble behaviour during sonothrombolysis. The blood and clot were assumed to be non-Newtonian and porous, respectively. The effects of ultrasound and microbubble parameters on flow-induced shear stress on the clot surface during stable and inertial cavitation were investigated. It was found that microbubble translation towards the clot and the shear stress on the clot surface during stable cavitation were significant when the bubble was about to undergo inertial cavitation. While insonation of large microbubble (radius of 1.65μm) at low frequency (0.50 MHz) produced the highest shear stress during stable cavitation, selection of these parameters is not as intuitive for inertial cavitation due to the strong competing effect between jet velocity and translational distance. An increase in jet velocity is always accompanied by a decrease in the translational distance and vice versa. Therefore, a right balance between the jet velocity and the translational distance is critical to maximise the shear stress on the clot surface. A jet velocity of 303 m/s and a distance travelled of 5.12μm at an initial bubble-clot separation of 10μm produced the greatest clot surface shear stress. This is achievable by insonating a 0.55μm microbubble using 0.50 MHz and 600 kPa ultrasound.
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spelling ntu-10356/1800642024-09-14T16:48:29Z Modelling the dynamics of microbubble undergoing stable and inertial cavitation: delineating the effects of ultrasound and microbubble parameters on sonothrombolysis Tan, Zhi Qi Ooi, Ean Hin Chiew, Yeong Shiong Foo, Ji Jinn Ng, Yin Kwee Ooi, Ean Tat School of Mechanical and Aerospace Engineering Engineering Acoustic waves Cavitation Sonothrombolysis induces clot breakdown using ultrasound waves to excite microbubbles. Despite the great potential, selecting optimal ultrasound (frequency and pressure) and microbubble (radius) parameters remains a challenge. To address this, a computational model was developed to investigate the bubble behaviour during sonothrombolysis. The blood and clot were assumed to be non-Newtonian and porous, respectively. The effects of ultrasound and microbubble parameters on flow-induced shear stress on the clot surface during stable and inertial cavitation were investigated. It was found that microbubble translation towards the clot and the shear stress on the clot surface during stable cavitation were significant when the bubble was about to undergo inertial cavitation. While insonation of large microbubble (radius of 1.65μm) at low frequency (0.50 MHz) produced the highest shear stress during stable cavitation, selection of these parameters is not as intuitive for inertial cavitation due to the strong competing effect between jet velocity and translational distance. An increase in jet velocity is always accompanied by a decrease in the translational distance and vice versa. Therefore, a right balance between the jet velocity and the translational distance is critical to maximise the shear stress on the clot surface. A jet velocity of 303 m/s and a distance travelled of 5.12μm at an initial bubble-clot separation of 10μm produced the greatest clot surface shear stress. This is achievable by insonating a 0.55μm microbubble using 0.50 MHz and 600 kPa ultrasound. Published version 2024-09-11T07:41:26Z 2024-09-11T07:41:26Z 2024 Journal Article Tan, Z. Q., Ooi, E. H., Chiew, Y. S., Foo, J. J., Ng, Y. K. & Ooi, E. T. (2024). Modelling the dynamics of microbubble undergoing stable and inertial cavitation: delineating the effects of ultrasound and microbubble parameters on sonothrombolysis. Biocybernetics and Biomedical Engineering, 44(2), 358-368. https://dx.doi.org/10.1016/j.bbe.2024.04.003 0208-5216 https://hdl.handle.net/10356/180064 10.1016/j.bbe.2024.04.003 2-s2.0-85192005087 2 44 358 368 en Biocybernetics and Biomedical Engineering © 2024 The Author(s). Published by Elsevier B.V. on behalf of Nalecz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). application/pdf
spellingShingle Engineering
Acoustic waves
Cavitation
Tan, Zhi Qi
Ooi, Ean Hin
Chiew, Yeong Shiong
Foo, Ji Jinn
Ng, Yin Kwee
Ooi, Ean Tat
Modelling the dynamics of microbubble undergoing stable and inertial cavitation: delineating the effects of ultrasound and microbubble parameters on sonothrombolysis
title Modelling the dynamics of microbubble undergoing stable and inertial cavitation: delineating the effects of ultrasound and microbubble parameters on sonothrombolysis
title_full Modelling the dynamics of microbubble undergoing stable and inertial cavitation: delineating the effects of ultrasound and microbubble parameters on sonothrombolysis
title_fullStr Modelling the dynamics of microbubble undergoing stable and inertial cavitation: delineating the effects of ultrasound and microbubble parameters on sonothrombolysis
title_full_unstemmed Modelling the dynamics of microbubble undergoing stable and inertial cavitation: delineating the effects of ultrasound and microbubble parameters on sonothrombolysis
title_short Modelling the dynamics of microbubble undergoing stable and inertial cavitation: delineating the effects of ultrasound and microbubble parameters on sonothrombolysis
title_sort modelling the dynamics of microbubble undergoing stable and inertial cavitation delineating the effects of ultrasound and microbubble parameters on sonothrombolysis
topic Engineering
Acoustic waves
Cavitation
url https://hdl.handle.net/10356/180064
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