Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function

Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function

Variants at the SLC30A8 locus are associated with type 2 diabetes (T2D) risk. The lead variant, rs13266634, encodes an amino acid change, Arg325Trp (R325W), at the C-terminus of the secretory granule-enriched zinc transporter, ZnT8. Although this protein-coding variant was previously thought to be t...

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Bibliographic Details
Main Authors: Hu, Ming, Kim, Innah, Morán, Ignasi, Peng, Weicong, Sun, Orien, Bonnefond, Amélie, Khamis, Amna, Bonàs-Guarch, Sílvia, Froguel, Philippe, Rutter, Guy A.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Transcriptional regulation
Risk variant
Online Access:https://hdl.handle.net/10356/180091

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