Predicting new-baseline glomerular filtration rate (NBGFR) after donor nephrectomy: validation of a split renal function (SRF)-based formula
Background: Accurate prediction of post-donor nephrectomy (DN) glomerular filtration rate is potentially useful for evaluating and counselling living kidney donors. Currently, there are limited tools to evaluate post-operative new-baseline glomerular filtration rate (NBGFR) in kidney donors. We aim...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/10356/180131 |
| _version_ | 1826114291367936000 |
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| author | Wong, Nicholas Hoi Pong So, Wei Zheng Gauhar, Vineet Goh, Benjamin Yen Seow Tiong, Ho Yee |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Wong, Nicholas Hoi Pong So, Wei Zheng Gauhar, Vineet Goh, Benjamin Yen Seow Tiong, Ho Yee |
| author_sort | Wong, Nicholas Hoi Pong |
| collection | NTU |
| description | Background: Accurate prediction of post-donor nephrectomy (DN) glomerular filtration rate is potentially useful for evaluating and counselling living kidney donors. Currently, there are limited tools to evaluate post-operative new-baseline glomerular filtration rate (NBGFR) in kidney donors. We aim to validate a conceptually simple formula based on split renal function (SRF) previously developed for radical nephrectomy patients. Methods: Eighty-three consecutive patients who underwent DN from 2010 to 2016 were included. Pre-operative CT imaging and functional data including pre-DN baseline Global GFR (108.2 ± 13.2 mL/min/1.73m2) were included. Observed NBGFR was defined as the latest eGFR 3–12 months post-DN. SRF, defined as volume of the contralateral non-resected kidney normalised by total volume of kidneys, was determined from pre-operative cross-sectional imaging (49.2 ± 2.36%). The equation derived from Rathi et al. is as detailed: Predicted NBGFR = 1.24 × (Global GFR Pre-DN) x (SRF). Results: The relationship between predicted NBGFR (66.0 ± 8.29 mL/min/1.73m2) and observed NBGFR (74.9 ± 16.4 mL/min/1.73m2) was assessed by evaluating correlation coefficients, bias, precision, accuracy, and concordance. The new SRF-based formula for NBGFR prediction correlated strongly with observed post-operative NBGFR (Pearson’s r = 0.729) demonstrating minimal bias (median difference = 7.190 mL/min/1.73m2) with good accuracy (96.4% within ± 30%, 62.7% within ± 15%) and precision (IQR of bias = − 0.094 to 16.227). Conclusion: The SRF-based formula was also able to accurately discriminate all but one patient to an NBGFR of > 45 mL/min/1.73m2. We utilised the newly developed SRF-based formula for predicting NBGFR in a living kidney donor population. Counselling of donor post-operative renal outcomes may then be optimised pre-operatively. |
| first_indexed | 2024-10-01T03:36:46Z |
| format | Journal Article |
| id | ntu-10356/180131 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:36:46Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1801312024-09-18T05:26:42Z Predicting new-baseline glomerular filtration rate (NBGFR) after donor nephrectomy: validation of a split renal function (SRF)-based formula Wong, Nicholas Hoi Pong So, Wei Zheng Gauhar, Vineet Goh, Benjamin Yen Seow Tiong, Ho Yee Lee Kong Chian School of Medicine (LKCMedicine) Medicine, Health and Life Sciences Nephrectomy Donor nephrectomy Background: Accurate prediction of post-donor nephrectomy (DN) glomerular filtration rate is potentially useful for evaluating and counselling living kidney donors. Currently, there are limited tools to evaluate post-operative new-baseline glomerular filtration rate (NBGFR) in kidney donors. We aim to validate a conceptually simple formula based on split renal function (SRF) previously developed for radical nephrectomy patients. Methods: Eighty-three consecutive patients who underwent DN from 2010 to 2016 were included. Pre-operative CT imaging and functional data including pre-DN baseline Global GFR (108.2 ± 13.2 mL/min/1.73m2) were included. Observed NBGFR was defined as the latest eGFR 3–12 months post-DN. SRF, defined as volume of the contralateral non-resected kidney normalised by total volume of kidneys, was determined from pre-operative cross-sectional imaging (49.2 ± 2.36%). The equation derived from Rathi et al. is as detailed: Predicted NBGFR = 1.24 × (Global GFR Pre-DN) x (SRF). Results: The relationship between predicted NBGFR (66.0 ± 8.29 mL/min/1.73m2) and observed NBGFR (74.9 ± 16.4 mL/min/1.73m2) was assessed by evaluating correlation coefficients, bias, precision, accuracy, and concordance. The new SRF-based formula for NBGFR prediction correlated strongly with observed post-operative NBGFR (Pearson’s r = 0.729) demonstrating minimal bias (median difference = 7.190 mL/min/1.73m2) with good accuracy (96.4% within ± 30%, 62.7% within ± 15%) and precision (IQR of bias = − 0.094 to 16.227). Conclusion: The SRF-based formula was also able to accurately discriminate all but one patient to an NBGFR of > 45 mL/min/1.73m2. We utilised the newly developed SRF-based formula for predicting NBGFR in a living kidney donor population. Counselling of donor post-operative renal outcomes may then be optimised pre-operatively. 2024-09-18T05:26:42Z 2024-09-18T05:26:42Z 2024 Journal Article Wong, N. H. P., So, W. Z., Gauhar, V., Goh, B. Y. S. & Tiong, H. Y. (2024). Predicting new-baseline glomerular filtration rate (NBGFR) after donor nephrectomy: validation of a split renal function (SRF)-based formula. World Journal of Urology, 42(1), 50-. https://dx.doi.org/10.1007/s00345-023-04759-4 0724-4983 https://hdl.handle.net/10356/180131 10.1007/s00345-023-04759-4 38244074 2-s2.0-85182626805 1 42 50 en World Journal of Urology © 2024 The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. All rights reserved. |
| spellingShingle | Medicine, Health and Life Sciences Nephrectomy Donor nephrectomy Wong, Nicholas Hoi Pong So, Wei Zheng Gauhar, Vineet Goh, Benjamin Yen Seow Tiong, Ho Yee Predicting new-baseline glomerular filtration rate (NBGFR) after donor nephrectomy: validation of a split renal function (SRF)-based formula |
| title | Predicting new-baseline glomerular filtration rate (NBGFR) after donor nephrectomy: validation of a split renal function (SRF)-based formula |
| title_full | Predicting new-baseline glomerular filtration rate (NBGFR) after donor nephrectomy: validation of a split renal function (SRF)-based formula |
| title_fullStr | Predicting new-baseline glomerular filtration rate (NBGFR) after donor nephrectomy: validation of a split renal function (SRF)-based formula |
| title_full_unstemmed | Predicting new-baseline glomerular filtration rate (NBGFR) after donor nephrectomy: validation of a split renal function (SRF)-based formula |
| title_short | Predicting new-baseline glomerular filtration rate (NBGFR) after donor nephrectomy: validation of a split renal function (SRF)-based formula |
| title_sort | predicting new baseline glomerular filtration rate nbgfr after donor nephrectomy validation of a split renal function srf based formula |
| topic | Medicine, Health and Life Sciences Nephrectomy Donor nephrectomy |
| url | https://hdl.handle.net/10356/180131 |
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