Utilizing food waste in 3D-printed PLA formulations to achieve sustainable and customizable controlled delivery systems
This is the first study that explores blending polylactic acid (PLA) with various biomasses, including food wastes─brewer’s spent grain (BSG), spent coffee grounds (SCG), sesame cake (SC), and thermoplastic starch (TPS) biomass to create composite gastric floating drug delivery systems (GFDDS) throu...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/180150 |
| _version_ | 1811679422456004608 |
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| author | Wang, Liwen Yong, Ling Xin Loo, Joachim Say Chye |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Wang, Liwen Yong, Ling Xin Loo, Joachim Say Chye |
| author_sort | Wang, Liwen |
| collection | NTU |
| description | This is the first study that explores blending polylactic acid (PLA) with various biomasses, including food wastes─brewer’s spent grain (BSG), spent coffee grounds (SCG), sesame cake (SC), and thermoplastic starch (TPS) biomass to create composite gastric floating drug delivery systems (GFDDS) through 3D printing. The aim is to investigate the influence of biomass percentage, biomass type, and printing parameters on their corresponding drug release profiles. 3D-printed (3DP) composite filaments were prepared by blending biomasses and PLA before in vitro drug release studies were performed using hydrophilic and hydrophobic model drugs, metoprolol tartrate (MT), and risperidone (RIS). The data revealed that release profiles were influenced by composite compositions and wall thicknesses of 3DP GFDDS capsules. Up to 15% of food waste could be blended with PLA for all food waste types tested. Delivery studies for PLA-food wastes found that MT was fully released by 4 h, exhibiting burst release profiles after a lag time of 0.5 to 1.5 h, and RIS could achieve a sustained release profile of approximately 48 h. PLA-TPS was utilized as a comparison and demonstrated variable release profiles ranging from 8 to 120 h, depending on the TPS content. The results demonstrated the potential for adjusting drug release profiles by incorporating affordable biomasses into GFDDS. This study presents a promising direction for creating delivery systems that are sustainable, customizable, and cost-effective, utilizing sustainable materials that can also be employed for agricultural, nutraceutical, personal care, and wastewater treatment applications. |
| first_indexed | 2024-10-01T03:08:54Z |
| format | Journal Article |
| id | ntu-10356/180150 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:08:54Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1801502024-09-27T15:44:38Z Utilizing food waste in 3D-printed PLA formulations to achieve sustainable and customizable controlled delivery systems Wang, Liwen Yong, Ling Xin Loo, Joachim Say Chye School of Materials Science and Engineering Lee Kong Chian School of Medicine (LKCMedicine) Singapore Centre for Environmental Life Sciences and Engineering (SCELSE) Engineering Medicine, Health and Life Sciences 3D printing Food waste Upcycling This is the first study that explores blending polylactic acid (PLA) with various biomasses, including food wastes─brewer’s spent grain (BSG), spent coffee grounds (SCG), sesame cake (SC), and thermoplastic starch (TPS) biomass to create composite gastric floating drug delivery systems (GFDDS) through 3D printing. The aim is to investigate the influence of biomass percentage, biomass type, and printing parameters on their corresponding drug release profiles. 3D-printed (3DP) composite filaments were prepared by blending biomasses and PLA before in vitro drug release studies were performed using hydrophilic and hydrophobic model drugs, metoprolol tartrate (MT), and risperidone (RIS). The data revealed that release profiles were influenced by composite compositions and wall thicknesses of 3DP GFDDS capsules. Up to 15% of food waste could be blended with PLA for all food waste types tested. Delivery studies for PLA-food wastes found that MT was fully released by 4 h, exhibiting burst release profiles after a lag time of 0.5 to 1.5 h, and RIS could achieve a sustained release profile of approximately 48 h. PLA-TPS was utilized as a comparison and demonstrated variable release profiles ranging from 8 to 120 h, depending on the TPS content. The results demonstrated the potential for adjusting drug release profiles by incorporating affordable biomasses into GFDDS. This study presents a promising direction for creating delivery systems that are sustainable, customizable, and cost-effective, utilizing sustainable materials that can also be employed for agricultural, nutraceutical, personal care, and wastewater treatment applications. Ministry of Education (MOE) Singapore Food Agency Published version This work was supported by the Singapore Food Agency (SFS_RND_SUFP_001_06) and the Ministry of Education (RG79/22). 2024-09-23T05:34:42Z 2024-09-23T05:34:42Z 2024 Journal Article Wang, L., Yong, L. X. & Loo, J. S. C. (2024). Utilizing food waste in 3D-printed PLA formulations to achieve sustainable and customizable controlled delivery systems. ACS Omega, 9(31), 34140-34150. https://dx.doi.org/10.1021/acsomega.4c05155 2470-1343 https://hdl.handle.net/10356/180150 10.1021/acsomega.4c05155 31 9 34140 34150 en SFS_RND_SUFP_001_06 RG79/22 ACS Omega © 2024 The Authors. Published byAmerican Chemical Society. This publication is licensed under CC-BY-NC-ND 4.0. application/pdf application/pdf |
| spellingShingle | Engineering Medicine, Health and Life Sciences 3D printing Food waste Upcycling Wang, Liwen Yong, Ling Xin Loo, Joachim Say Chye Utilizing food waste in 3D-printed PLA formulations to achieve sustainable and customizable controlled delivery systems |
| title | Utilizing food waste in 3D-printed PLA formulations to achieve sustainable and customizable controlled delivery systems |
| title_full | Utilizing food waste in 3D-printed PLA formulations to achieve sustainable and customizable controlled delivery systems |
| title_fullStr | Utilizing food waste in 3D-printed PLA formulations to achieve sustainable and customizable controlled delivery systems |
| title_full_unstemmed | Utilizing food waste in 3D-printed PLA formulations to achieve sustainable and customizable controlled delivery systems |
| title_short | Utilizing food waste in 3D-printed PLA formulations to achieve sustainable and customizable controlled delivery systems |
| title_sort | utilizing food waste in 3d printed pla formulations to achieve sustainable and customizable controlled delivery systems |
| topic | Engineering Medicine, Health and Life Sciences 3D printing Food waste Upcycling |
| url | https://hdl.handle.net/10356/180150 |
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