A new discovery on the potential stability of ion-selective membranes: the poison from tetrahydrofuran
Ion-selective electrodes (ISEs) have widespread use in the fields of clinical and environmental analyses. Tetrahydrofuran (THF) is the most used solvent for the preparation of modern ISEs, equipped with ion-selective membranes (ISMs). Until now, the influence of impurities in THF towards potentiomet...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/180478 |
| _version_ | 1826113870946631680 |
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| author | Mao, Canwei Zhao, Ke Loong, Cyrus Foo Fit Song, Dean Lisak, Grzegorz |
| author2 | School of Civil and Environmental Engineering |
| author_facet | School of Civil and Environmental Engineering Mao, Canwei Zhao, Ke Loong, Cyrus Foo Fit Song, Dean Lisak, Grzegorz |
| author_sort | Mao, Canwei |
| collection | NTU |
| description | Ion-selective electrodes (ISEs) have widespread use in the fields of clinical and environmental analyses. Tetrahydrofuran (THF) is the most used solvent for the preparation of modern ISEs, equipped with ion-selective membranes (ISMs). Until now, the influence of impurities in THF towards potentiometric instability of ion-selective membrane based ISEs was prob-ably associated with either presence of residual water or peroxide. To address this issue, most literature recommends to re-distil THF prior to the use in preparation of the potentiometric membranes. Current study reveals that the actual THF impu-rity that is responsible for potential instability in the ISM includes products from the oxidation of THF, which contains hy-droxyl group and possibly carbonyl group with boiling point of above 200 °C. The density functional theory supported pathway of chemical reaction of THF oxidation, hence the chemical structure of the uncertain impurities was predicted. The underlying reason for the deteriorating potential stability of the ISEs is proposed as the significant hydrophilicity of these impurities that affect the partitioning of the ion sensing components in the membrane and thus enhancing the leaching of the membrane components from membrane phase. This finding explains why re-distillation of aged THF is advised. |
| first_indexed | 2025-03-09T10:58:17Z |
| format | Journal Article |
| id | ntu-10356/180478 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-03-09T10:58:17Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1804782024-10-09T15:35:14Z A new discovery on the potential stability of ion-selective membranes: the poison from tetrahydrofuran Mao, Canwei Zhao, Ke Loong, Cyrus Foo Fit Song, Dean Lisak, Grzegorz School of Civil and Environmental Engineering Nanyang Environment and Water Research Institute Residues and Resource Reclamation Centre Chemistry Potentiometry Potential stability Ion-selective electrodes (ISEs) have widespread use in the fields of clinical and environmental analyses. Tetrahydrofuran (THF) is the most used solvent for the preparation of modern ISEs, equipped with ion-selective membranes (ISMs). Until now, the influence of impurities in THF towards potentiometric instability of ion-selective membrane based ISEs was prob-ably associated with either presence of residual water or peroxide. To address this issue, most literature recommends to re-distil THF prior to the use in preparation of the potentiometric membranes. Current study reveals that the actual THF impu-rity that is responsible for potential instability in the ISM includes products from the oxidation of THF, which contains hy-droxyl group and possibly carbonyl group with boiling point of above 200 °C. The density functional theory supported pathway of chemical reaction of THF oxidation, hence the chemical structure of the uncertain impurities was predicted. The underlying reason for the deteriorating potential stability of the ISEs is proposed as the significant hydrophilicity of these impurities that affect the partitioning of the ion sensing components in the membrane and thus enhancing the leaching of the membrane components from membrane phase. This finding explains why re-distillation of aged THF is advised. Agency for Science, Technology and Research (A*STAR) National Research Foundation (NRF) Public Utilities Board (PUB) Submitted/Accepted version This work was supported by Agency for Science, Technologyand Research (A*STAR) under Industry Alignment Fund−Industry Collaboration Project [Project Reference No.:I2101E0006]. his research was alsosupported by the National Research Foundation, Singapore,and PUB, Singapore’s National Water Agency under itsRIE2025 Urban Solutions and Sustainability (USS) (Water)Centre of Excellence (CoE) Programme which providesfunding to the Nanyang Environment & Water ResearchInstitute (NEWRI) of the Nanyang Technological University,Singapore (NTU). 2024-10-09T01:49:28Z 2024-10-09T01:49:28Z 2024 Journal Article Mao, C., Zhao, K., Loong, C. F. F., Song, D. & Lisak, G. (2024). A new discovery on the potential stability of ion-selective membranes: the poison from tetrahydrofuran. ACS Sensors, 9(8), 3870-3876. https://dx.doi.org/10.1021/acssensors.4c01673 2379-3694 https://hdl.handle.net/10356/180478 10.1021/acssensors.4c01673 8 9 3870 3876 en I2101E0006 ACS Sensors © 2024 American Chemical Society. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1021/acssensors.4c01673. application/pdf application/pdf |
| spellingShingle | Chemistry Potentiometry Potential stability Mao, Canwei Zhao, Ke Loong, Cyrus Foo Fit Song, Dean Lisak, Grzegorz A new discovery on the potential stability of ion-selective membranes: the poison from tetrahydrofuran |
| title | A new discovery on the potential stability of ion-selective membranes: the poison from tetrahydrofuran |
| title_full | A new discovery on the potential stability of ion-selective membranes: the poison from tetrahydrofuran |
| title_fullStr | A new discovery on the potential stability of ion-selective membranes: the poison from tetrahydrofuran |
| title_full_unstemmed | A new discovery on the potential stability of ion-selective membranes: the poison from tetrahydrofuran |
| title_short | A new discovery on the potential stability of ion-selective membranes: the poison from tetrahydrofuran |
| title_sort | new discovery on the potential stability of ion selective membranes the poison from tetrahydrofuran |
| topic | Chemistry Potentiometry Potential stability |
| url | https://hdl.handle.net/10356/180478 |
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