Magnetic miniature soft robot with reprogrammable drug-dispensing functionalities: toward advanced targeted combination therapy
Miniature robots are untethered actuators, which have great prospects to transform targeted drug delivery because they can potentially deliver high concentrations of medicine to the disease site(s) with minimal complications. However, existing miniature robots cannot perform advanced targeted combin...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/180531 |
| _version_ | 1826110090471538688 |
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| author | Yang, Zilin Xu, Changyu Lee, Jia Xin Lum, Guo Zhan |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Yang, Zilin Xu, Changyu Lee, Jia Xin Lum, Guo Zhan |
| author_sort | Yang, Zilin |
| collection | NTU |
| description | Miniature robots are untethered actuators, which have great prospects to transform targeted drug delivery because they can potentially deliver high concentrations of medicine to the disease site(s) with minimal complications. However, existing miniature robots cannot perform advanced targeted combination therapy; majority of them can at most transport one type of drug, while those that can carry multiple drugs are unable to change their drug-dispensing sequence and dosage. Furthermore, the latter robots cannot transport more than three types of drugs, selectively dispense their drugs, maintain their mobility, or release their drugs at multiple sites. Here, a millimeter-scale soft robot is proposed, which can be actuated by alternating magnetic fields to dispense four types of drugs with reprogrammable drug-dispensing sequence and dosage (dispensing rates: 0.0992–0.231 µL h−1). This robot has six degrees-of-freedom motions, and it can deliver its drugs to multiple desired sites by rolling and two-anchor crawling across unstructured environments with negligible drug leakage. Such dexterity is highly desirable and unprecedented for miniature robots with drug-dispensing capabilities. The soft robot therefore has great potential to enable advanced targeted combination therapy, where four types of drugs must be delivered to various disease sites, each with a specific sequence and dosage of drugs. |
| first_indexed | 2025-03-09T09:58:12Z |
| format | Journal Article |
| id | ntu-10356/180531 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-03-09T09:58:12Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1805312024-10-12T16:48:16Z Magnetic miniature soft robot with reprogrammable drug-dispensing functionalities: toward advanced targeted combination therapy Yang, Zilin Xu, Changyu Lee, Jia Xin Lum, Guo Zhan School of Mechanical and Aerospace Engineering Rehabilitation Research Institute of Singapore (RRIS) Medicine, Health and Life Sciences Magnetic materials Small-scale actuator Miniature robots are untethered actuators, which have great prospects to transform targeted drug delivery because they can potentially deliver high concentrations of medicine to the disease site(s) with minimal complications. However, existing miniature robots cannot perform advanced targeted combination therapy; majority of them can at most transport one type of drug, while those that can carry multiple drugs are unable to change their drug-dispensing sequence and dosage. Furthermore, the latter robots cannot transport more than three types of drugs, selectively dispense their drugs, maintain their mobility, or release their drugs at multiple sites. Here, a millimeter-scale soft robot is proposed, which can be actuated by alternating magnetic fields to dispense four types of drugs with reprogrammable drug-dispensing sequence and dosage (dispensing rates: 0.0992–0.231 µL h−1). This robot has six degrees-of-freedom motions, and it can deliver its drugs to multiple desired sites by rolling and two-anchor crawling across unstructured environments with negligible drug leakage. Such dexterity is highly desirable and unprecedented for miniature robots with drug-dispensing capabilities. The soft robot therefore has great potential to enable advanced targeted combination therapy, where four types of drugs must be delivered to various disease sites, each with a specific sequence and dosage of drugs. Submitted/Accepted version 2024-10-10T03:13:26Z 2024-10-10T03:13:26Z 2024 Journal Article Yang, Z., Xu, C., Lee, J. X. & Lum, G. Z. (2024). Magnetic miniature soft robot with reprogrammable drug-dispensing functionalities: toward advanced targeted combination therapy. Advanced Materials. https://dx.doi.org/10.1002/adma.202408750 0935-9648 https://hdl.handle.net/10356/180531 10.1002/adma.202408750 2-s2.0-85203281969 en Advanced Materials © 2024 Wiley-VCH GmbH. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1002/adma.202408750. application/pdf application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Magnetic materials Small-scale actuator Yang, Zilin Xu, Changyu Lee, Jia Xin Lum, Guo Zhan Magnetic miniature soft robot with reprogrammable drug-dispensing functionalities: toward advanced targeted combination therapy |
| title | Magnetic miniature soft robot with reprogrammable drug-dispensing functionalities: toward advanced targeted combination therapy |
| title_full | Magnetic miniature soft robot with reprogrammable drug-dispensing functionalities: toward advanced targeted combination therapy |
| title_fullStr | Magnetic miniature soft robot with reprogrammable drug-dispensing functionalities: toward advanced targeted combination therapy |
| title_full_unstemmed | Magnetic miniature soft robot with reprogrammable drug-dispensing functionalities: toward advanced targeted combination therapy |
| title_short | Magnetic miniature soft robot with reprogrammable drug-dispensing functionalities: toward advanced targeted combination therapy |
| title_sort | magnetic miniature soft robot with reprogrammable drug dispensing functionalities toward advanced targeted combination therapy |
| topic | Medicine, Health and Life Sciences Magnetic materials Small-scale actuator |
| url | https://hdl.handle.net/10356/180531 |
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