Dual p38MAPK and MEK inhibition disrupts adaptive chemoresistance in mesenchymal glioblastoma to temozolomide

Dual p38MAPK and MEK inhibition disrupts adaptive chemoresistance in mesenchymal glioblastoma to temozolomide

Background: Precision treatment of glioblastoma is increasingly focused on molecular subtyping, with the mesenchymal subtype particularly resistant to temozolomide. Here, we aim to develop a targeted therapy for temozolomide resensitization in the mesenchymal subtype. Methods: We integrated kinomic...

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Bibliographic Details
Main Authors: Cheng, Hong Sheng, Chong, Yuk Kien, Lim, Eldeen Kai Yi, Lee, Xin Yi, Pang, Qing You, Novera, Wisna, Marvalim, Charlie, Lee, Jeannie Xue Ting, Ang, Beng Ti, Tang, Carol, Tan, Nguan Soon
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Brain cancer
Glioma
Online Access:https://hdl.handle.net/10356/180688

Internet

https://hdl.handle.net/10356/180688

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