In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds
Polycaprolactone (PCL) scaffolds that are produced through additive manufacturing are one of the most researched bone tissue engineering structures in the field. Due to the intrinsic limitations of PCL, carbon nanomaterials are often investigated to reinforce the PCL scaffolds. Despite several studi...
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/180787 |
| _version_ | 1826110759622410240 |
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| author | Hou, Yanhao Wang, Weiguang Bartolo, Paulo |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Hou, Yanhao Wang, Weiguang Bartolo, Paulo |
| author_sort | Hou, Yanhao |
| collection | NTU |
| description | Polycaprolactone (PCL) scaffolds that are produced through additive manufacturing are one of the most researched bone tissue engineering structures in the field. Due to the intrinsic limitations of PCL, carbon nanomaterials are often investigated to reinforce the PCL scaffolds. Despite several studies that have been conducted on carbon nanomaterials, such as graphene (G) and graphene oxide (GO), certain challenges remain in terms of the precise design of the biological and nonbiological properties of the scaffolds. This paper addresses this limitation by investigating both the nonbiological (element composition, surface, degradation, and thermal and mechanical properties) and biological characteristics of carbon nanomaterial-reinforced PCL scaffolds for bone tissue engineering applications. Results showed that the incorporation of G and GO increased surface properties (reduced modulus and wettability), material crystallinity, crystallization temperature, and degradation rate. However, the variations in compressive modulus, strength, surface hardness, and cell metabolic activity strongly depended on the type of reinforcement. Finally, a series of phenomenological models were developed based on experimental results to describe the variations of scaffold’s weight, fiber diameter, porosity, and mechanical properties as functions of degradation time and carbon nanomaterial concentrations. The results presented in this paper enable the design of three-dimensional (3D) bone scaffolds with tuned properties by adjusting the type and concentration of different functional fillers. Graphic abstract: (Figure presented.) |
| first_indexed | 2025-03-09T10:08:50Z |
| format | Journal Article |
| id | ntu-10356/180787 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-03-09T10:08:50Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1807872024-10-25T01:51:04Z In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds Hou, Yanhao Wang, Weiguang Bartolo, Paulo School of Mechanical and Aerospace Engineering Singapore Centre for 3D Printing Engineering Additive manufacturing Carbon nanomaterial Polycaprolactone (PCL) scaffolds that are produced through additive manufacturing are one of the most researched bone tissue engineering structures in the field. Due to the intrinsic limitations of PCL, carbon nanomaterials are often investigated to reinforce the PCL scaffolds. Despite several studies that have been conducted on carbon nanomaterials, such as graphene (G) and graphene oxide (GO), certain challenges remain in terms of the precise design of the biological and nonbiological properties of the scaffolds. This paper addresses this limitation by investigating both the nonbiological (element composition, surface, degradation, and thermal and mechanical properties) and biological characteristics of carbon nanomaterial-reinforced PCL scaffolds for bone tissue engineering applications. Results showed that the incorporation of G and GO increased surface properties (reduced modulus and wettability), material crystallinity, crystallization temperature, and degradation rate. However, the variations in compressive modulus, strength, surface hardness, and cell metabolic activity strongly depended on the type of reinforcement. Finally, a series of phenomenological models were developed based on experimental results to describe the variations of scaffold’s weight, fiber diameter, porosity, and mechanical properties as functions of degradation time and carbon nanomaterial concentrations. The results presented in this paper enable the design of three-dimensional (3D) bone scaffolds with tuned properties by adjusting the type and concentration of different functional fillers. Graphic abstract: (Figure presented.) The authors wish to acknowledge Engineering and Physical Sciences Research Council (EPSRC) UK for the Global Challenges Research Fund (No. EP/R015139/1), and Rosetrees Trust UK & Stoneygate Trust UK for the Enterprise Fellowship (Ref: M874). 2024-10-25T01:51:04Z 2024-10-25T01:51:04Z 2024 Journal Article Hou, Y., Wang, W. & Bartolo, P. (2024). In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds. Bio-Design and Manufacturing, 7(5), 651-669. https://dx.doi.org/10.1007/s42242-024-00280-8 2096-5524 https://hdl.handle.net/10356/180787 10.1007/s42242-024-00280-8 2-s2.0-85200327176 5 7 651 669 en Bio-Design and Manufacturing © 2024 The Author(s). All rights reserved. |
| spellingShingle | Engineering Additive manufacturing Carbon nanomaterial Hou, Yanhao Wang, Weiguang Bartolo, Paulo In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds |
| title | In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds |
| title_full | In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds |
| title_fullStr | In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds |
| title_full_unstemmed | In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds |
| title_short | In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds |
| title_sort | in vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds |
| topic | Engineering Additive manufacturing Carbon nanomaterial |
| url | https://hdl.handle.net/10356/180787 |
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