Infection and the microbiome in bronchiectasis
Bronchiectasis is marked by bronchial dilatation, recurrent infections and significant morbidity, underpinned by a complex interplay between microbial dysbiosis and immune dysregulation. The identification of distinct endophenotypes have refined our understanding of its pathogenesis, including its h...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/180999 |
| _version_ | 1826125202194432000 |
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| author | Mac Aogáin, Micheál Dicker, Alison J. Mertsch, Pontus Chotirmall, Sanjay Haresh |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Mac Aogáin, Micheál Dicker, Alison J. Mertsch, Pontus Chotirmall, Sanjay Haresh |
| author_sort | Mac Aogáin, Micheál |
| collection | NTU |
| description | Bronchiectasis is marked by bronchial dilatation, recurrent infections and significant morbidity, underpinned by a complex interplay between microbial dysbiosis and immune dysregulation. The identification of distinct endophenotypes have refined our understanding of its pathogenesis, including its heterogeneous disease mechanisms that influence treatment and prognosis responses. Next-generation sequencing (NGS) has revolutionised the way we view airway microbiology, allowing insights into the "unculturable". Understanding the bronchiectasis microbiome through targeted amplicon sequencing and/or shotgun metagenomics has provided key information on the interplay of the microbiome and host immunity, a central feature of disease progression. The rapid increase in translational and clinical studies in bronchiectasis now provides scope for the application of precision medicine and a better understanding of the efficacy of interventions aimed at restoring microbial balance and/or modulating immune responses. Holistic integration of these insights is driving an evolving paradigm shift in our understanding of bronchiectasis, which includes the critical role of the microbiome and its unique interplay with clinical, inflammatory, immunological and metabolic factors. Here, we review the current state of infection and the microbiome in bronchiectasis and provide views on the future directions in this field. |
| first_indexed | 2025-03-09T13:58:23Z |
| format | Journal Article |
| id | ntu-10356/180999 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-03-09T13:58:23Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1809992024-11-17T15:40:37Z Infection and the microbiome in bronchiectasis Mac Aogáin, Micheál Dicker, Alison J. Mertsch, Pontus Chotirmall, Sanjay Haresh Lee Kong Chian School of Medicine (LKCMedicine) Tan Tock Seng Hospital Medicine, Health and Life Sciences Bacterial infection Bronchiectasis Bronchiectasis is marked by bronchial dilatation, recurrent infections and significant morbidity, underpinned by a complex interplay between microbial dysbiosis and immune dysregulation. The identification of distinct endophenotypes have refined our understanding of its pathogenesis, including its heterogeneous disease mechanisms that influence treatment and prognosis responses. Next-generation sequencing (NGS) has revolutionised the way we view airway microbiology, allowing insights into the "unculturable". Understanding the bronchiectasis microbiome through targeted amplicon sequencing and/or shotgun metagenomics has provided key information on the interplay of the microbiome and host immunity, a central feature of disease progression. The rapid increase in translational and clinical studies in bronchiectasis now provides scope for the application of precision medicine and a better understanding of the efficacy of interventions aimed at restoring microbial balance and/or modulating immune responses. Holistic integration of these insights is driving an evolving paradigm shift in our understanding of bronchiectasis, which includes the critical role of the microbiome and its unique interplay with clinical, inflammatory, immunological and metabolic factors. Here, we review the current state of infection and the microbiome in bronchiectasis and provide views on the future directions in this field. Ministry of Education (MOE) Ministry of Health (MOH) National Medical Research Council (NMRC) Published version This work was supported by the Singapore Ministry of Health’s National Medical Research Council under its Clinician-Scientist Individual Research Grant (MOH-001356) (S.H. Chotirmall) and Clinician Scientist Award (MOH-000710) (S.H. Chotirmall), and the Singapore Ministry of Education under its AcRF Tier 1 Grant (RT1/22) (S.H. Chotirmall). Funding information for this article has been deposited with the Crossref Funder Registry. 2024-11-11T01:12:18Z 2024-11-11T01:12:18Z 2024 Journal Article Mac Aogáin, M., Dicker, A. J., Mertsch, P. & Chotirmall, S. H. (2024). Infection and the microbiome in bronchiectasis. European Respiratory Review, 33(173), 240038-. https://dx.doi.org/10.1183/16000617.0038-2024 0905-9180 https://hdl.handle.net/10356/180999 10.1183/16000617.0038-2024 38960615 2-s2.0-85199634258 173 33 240038 en MOH-001356 MOH-000710 RT1/22 European Respiratory Review © 2024 The authors. This version is distributed under the terms of the Creative Commons Attribution NonCommercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Bacterial infection Bronchiectasis Mac Aogáin, Micheál Dicker, Alison J. Mertsch, Pontus Chotirmall, Sanjay Haresh Infection and the microbiome in bronchiectasis |
| title | Infection and the microbiome in bronchiectasis |
| title_full | Infection and the microbiome in bronchiectasis |
| title_fullStr | Infection and the microbiome in bronchiectasis |
| title_full_unstemmed | Infection and the microbiome in bronchiectasis |
| title_short | Infection and the microbiome in bronchiectasis |
| title_sort | infection and the microbiome in bronchiectasis |
| topic | Medicine, Health and Life Sciences Bacterial infection Bronchiectasis |
| url | https://hdl.handle.net/10356/180999 |
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