Deblurring, artifact-free optical coherence tomography with deconvolution-random phase modulation
Deconvolution is a commonly employed technique for enhancing image quality in optical imaging methods. Unfortunately, its application in optical coherence tomography (OCT) is often hindered by sensitivity to noise, which leads to additive ringing artifacts. These artifacts considerably degrade the q...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/181018 |
| _version_ | 1826127746599747584 |
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| author | Ge, Xin Chen, Si Lin, Kan Ni, Guangming Bo, En Wang, Lulu Liu, Linbo |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Ge, Xin Chen, Si Lin, Kan Ni, Guangming Bo, En Wang, Lulu Liu, Linbo |
| author_sort | Ge, Xin |
| collection | NTU |
| description | Deconvolution is a commonly employed technique for enhancing image quality in optical imaging methods. Unfortunately, its application in optical coherence tomography (OCT) is often hindered by sensitivity to noise, which leads to additive ringing artifacts. These artifacts considerably degrade the quality of deconvolved images, thereby limiting its effectiveness in OCT imaging. In this study, we propose a framework that integrates numerical random phase masks into the deconvolution process, effectively eliminating these artifacts and enhancing image clarity. The optimized joint operation of an iterative Richardson-Lucy deconvolution and numerical synthesis of random phase masks (RPM), termed as Deconv-RPM, enables a 2.5-fold reduction in full width at half-maximum (FWHM). We demonstrate that the Deconv-RPM method significantly enhances image clarity, allowing for the discernment of previously unresolved cellular-level details in nonkeratinized epithelial cells ex vivo and moving blood cells in vivo. |
| first_indexed | 2025-03-09T14:38:50Z |
| format | Journal Article |
| id | ntu-10356/181018 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-03-09T14:38:50Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1810182024-11-15T15:42:39Z Deblurring, artifact-free optical coherence tomography with deconvolution-random phase modulation Ge, Xin Chen, Si Lin, Kan Ni, Guangming Bo, En Wang, Lulu Liu, Linbo School of Electrical and Electronic Engineering School of Chemical and Biomedical Engineering Engineering Deconvolution Random phase masks Deconvolution is a commonly employed technique for enhancing image quality in optical imaging methods. Unfortunately, its application in optical coherence tomography (OCT) is often hindered by sensitivity to noise, which leads to additive ringing artifacts. These artifacts considerably degrade the quality of deconvolved images, thereby limiting its effectiveness in OCT imaging. In this study, we propose a framework that integrates numerical random phase masks into the deconvolution process, effectively eliminating these artifacts and enhancing image clarity. The optimized joint operation of an iterative Richardson-Lucy deconvolution and numerical synthesis of random phase masks (RPM), termed as Deconv-RPM, enables a 2.5-fold reduction in full width at half-maximum (FWHM). We demonstrate that the Deconv-RPM method significantly enhances image clarity, allowing for the discernment of previously unresolved cellular-level details in nonkeratinized epithelial cells ex vivo and moving blood cells in vivo. Ministry of Health (MOH) National Medical Research Council (NMRC) Published version This research is supported by the Guangdong Natural Science Fund General Program (2023A1515011289), Singapore Ministry of Health's National Medical Research Council under its Open Fund Individual Research Grant (MOH-OFIRG19may-0009), Ministry of Education Singapore under its Academic Research Fund Tier 1 (RG35/22) and its Academic Research Funding Tier 2 (MOE-T2EP30120-0001), and China-Singapore International Joint Research Institute (203-A022001) 2024-11-11T07:28:27Z 2024-11-11T07:28:27Z 2024 Journal Article Ge, X., Chen, S., Lin, K., Ni, G., Bo, E., Wang, L. & Liu, L. (2024). Deblurring, artifact-free optical coherence tomography with deconvolution-random phase modulation. Opto-Electronic Science, 3(1), 230020-230020. https://dx.doi.org/10.29026/oes.2024.230020 2097-0382 https://hdl.handle.net/10356/181018 10.29026/oes.2024.230020 2-s2.0-85198119027 1 3 230020 en RG35/22 MOE-T2EP30120-0001 203-A022001 Opto-Electronic Science © The Author(s) 2024. Published by Institute of Optics and Electronics, Chinese Academy of Sciences.This article is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. application/pdf |
| spellingShingle | Engineering Deconvolution Random phase masks Ge, Xin Chen, Si Lin, Kan Ni, Guangming Bo, En Wang, Lulu Liu, Linbo Deblurring, artifact-free optical coherence tomography with deconvolution-random phase modulation |
| title | Deblurring, artifact-free optical coherence tomography with deconvolution-random phase modulation |
| title_full | Deblurring, artifact-free optical coherence tomography with deconvolution-random phase modulation |
| title_fullStr | Deblurring, artifact-free optical coherence tomography with deconvolution-random phase modulation |
| title_full_unstemmed | Deblurring, artifact-free optical coherence tomography with deconvolution-random phase modulation |
| title_short | Deblurring, artifact-free optical coherence tomography with deconvolution-random phase modulation |
| title_sort | deblurring artifact free optical coherence tomography with deconvolution random phase modulation |
| topic | Engineering Deconvolution Random phase masks |
| url | https://hdl.handle.net/10356/181018 |
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