Bimetal-biligand frameworks for spatiotemporal nitric oxide-enhanced sono-immunotherapy
Sonodynamic therapy can trigger immunogenic cell death to augment immunotherapy, benefiting from its superior spatiotemporal selectivity and non-invasiveness. However, the practical applications of sonosensitizers are hindered by their low efficacy in killing cancer cells and activating immune respo...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Online Access: | https://hdl.handle.net/10356/181216 |
| _version_ | 1826123865215991808 |
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| author | Cheng, Yu Zhong, Wenbin Chen, Yun Tan, Brynne Shu Ni Zhao, Yue Guo, Jingjing Ma, Mengmeng Zhao, Yanli |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Cheng, Yu Zhong, Wenbin Chen, Yun Tan, Brynne Shu Ni Zhao, Yue Guo, Jingjing Ma, Mengmeng Zhao, Yanli |
| author_sort | Cheng, Yu |
| collection | NTU |
| description | Sonodynamic therapy can trigger immunogenic cell death to augment immunotherapy, benefiting from its superior spatiotemporal selectivity and non-invasiveness. However, the practical applications of sonosensitizers are hindered by their low efficacy in killing cancer cells and activating immune responses. Here, two US Food and Drug Administration-approved drug ligands (ferricyanide and nitroprusside) and two types of metals (copper/iron) are selected to construct a bimetal-biligand framework (Cu[PBA-NO]). Through elaborate regulation of multiple metal/ligand coordination, the systemically administered Cu[PBA-NO] nanoagent shows sono-catalytic and NO release ability under ultrasound irradiation, which can be used for effective sono-immunotherapy. Moreover, Cu[PBA-NO] can downregulate intracellular glutathione levels that would destroy intracellular redox homeostasis and facilitate reactive oxygen species accumulation. The released tumor-associated antigens subsequently facilitate dendritic cell maturation within the tumor-draining lymph node, effectively initiating a T cell-mediated immune response and thereby bolstering the capacity to identify and combat cancer cells. This study paves a new avenue for the efficient cancer sono-immunotherapy. |
| first_indexed | 2025-03-09T13:37:08Z |
| format | Journal Article |
| id | ntu-10356/181216 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-03-09T13:37:08Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1812162024-11-18T02:41:01Z Bimetal-biligand frameworks for spatiotemporal nitric oxide-enhanced sono-immunotherapy Cheng, Yu Zhong, Wenbin Chen, Yun Tan, Brynne Shu Ni Zhao, Yue Guo, Jingjing Ma, Mengmeng Zhao, Yanli School of Chemistry, Chemical Engineering and Biotechnology Engineering Bimetal-biligand frameworks Cancer treatment Sonodynamic therapy can trigger immunogenic cell death to augment immunotherapy, benefiting from its superior spatiotemporal selectivity and non-invasiveness. However, the practical applications of sonosensitizers are hindered by their low efficacy in killing cancer cells and activating immune responses. Here, two US Food and Drug Administration-approved drug ligands (ferricyanide and nitroprusside) and two types of metals (copper/iron) are selected to construct a bimetal-biligand framework (Cu[PBA-NO]). Through elaborate regulation of multiple metal/ligand coordination, the systemically administered Cu[PBA-NO] nanoagent shows sono-catalytic and NO release ability under ultrasound irradiation, which can be used for effective sono-immunotherapy. Moreover, Cu[PBA-NO] can downregulate intracellular glutathione levels that would destroy intracellular redox homeostasis and facilitate reactive oxygen species accumulation. The released tumor-associated antigens subsequently facilitate dendritic cell maturation within the tumor-draining lymph node, effectively initiating a T cell-mediated immune response and thereby bolstering the capacity to identify and combat cancer cells. This study paves a new avenue for the efficient cancer sono-immunotherapy. The authors acknowledge the support from the National Research Foundation Singapore under Its Competitive Research Programme (NRF-CRP26-2021-0002). 2024-11-18T02:41:01Z 2024-11-18T02:41:01Z 2024 Journal Article Cheng, Y., Zhong, W., Chen, Y., Tan, B. S. N., Zhao, Y., Guo, J., Ma, M. & Zhao, Y. (2024). Bimetal-biligand frameworks for spatiotemporal nitric oxide-enhanced sono-immunotherapy. Advanced Materials, 36(45), e2408242-. https://dx.doi.org/10.1002/adma.202408242 0935-9648 https://hdl.handle.net/10356/181216 10.1002/adma.202408242 39225414 2-s2.0-85202959029 45 36 e2408242 en NRF-CRP26-2021-0002 Advanced Materials © 2024 Wiley-VCH GmbH. All rights reserved. |
| spellingShingle | Engineering Bimetal-biligand frameworks Cancer treatment Cheng, Yu Zhong, Wenbin Chen, Yun Tan, Brynne Shu Ni Zhao, Yue Guo, Jingjing Ma, Mengmeng Zhao, Yanli Bimetal-biligand frameworks for spatiotemporal nitric oxide-enhanced sono-immunotherapy |
| title | Bimetal-biligand frameworks for spatiotemporal nitric oxide-enhanced sono-immunotherapy |
| title_full | Bimetal-biligand frameworks for spatiotemporal nitric oxide-enhanced sono-immunotherapy |
| title_fullStr | Bimetal-biligand frameworks for spatiotemporal nitric oxide-enhanced sono-immunotherapy |
| title_full_unstemmed | Bimetal-biligand frameworks for spatiotemporal nitric oxide-enhanced sono-immunotherapy |
| title_short | Bimetal-biligand frameworks for spatiotemporal nitric oxide-enhanced sono-immunotherapy |
| title_sort | bimetal biligand frameworks for spatiotemporal nitric oxide enhanced sono immunotherapy |
| topic | Engineering Bimetal-biligand frameworks Cancer treatment |
| url | https://hdl.handle.net/10356/181216 |
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