Development of novel CRISPR-Cas9 protein scaffolds and base editors - engineering a smaller SpCas9
CRISPR-Cas system holds immense potential for treatment of genetic diseases. However, therapeutic adoption of CRISPR-Cas9 system still faces issues with safety and efficient delivery in vivo. Gene editing with Cas9 can potentially treat genetic diseases at its root cause. However, this classically r...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2024
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| Online Access: | https://hdl.handle.net/10356/181295 |