Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging
Photoacoustic tomography offers a powerful tool to visualize biologically relevant molecules and understand processes within living systems at high resolution in deep tissue, facilitated by the conversion of incident photons into low-scattering acoustic waves through non-radiative relaxation. Althou...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/181311 |
| _version_ | 1826121031708835840 |
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| author | Loh, Kang Yong Li, Lei S. Fan, Jingyue Goh, Yi Yiing Liew, Weng Heng Davis, Samuel Zhang, Yide Li, Kai Liu, Jie Liang, Liangliang Feng, Minjun Yang, Ming Zhang, Hang Ma, Ping’an Feng, Guangxue Mu, Zhao Gao, Weibo Sum, Tze Chien Liu, Bin Lin, Jun Yao, Kui Wang, Lihong V. Liu, Xiaogang |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Loh, Kang Yong Li, Lei S. Fan, Jingyue Goh, Yi Yiing Liew, Weng Heng Davis, Samuel Zhang, Yide Li, Kai Liu, Jie Liang, Liangliang Feng, Minjun Yang, Ming Zhang, Hang Ma, Ping’an Feng, Guangxue Mu, Zhao Gao, Weibo Sum, Tze Chien Liu, Bin Lin, Jun Yao, Kui Wang, Lihong V. Liu, Xiaogang |
| author_sort | Loh, Kang Yong |
| collection | NTU |
| description | Photoacoustic tomography offers a powerful tool to visualize biologically relevant molecules and understand processes within living systems at high resolution in deep tissue, facilitated by the conversion of incident photons into low-scattering acoustic waves through non-radiative relaxation. Although current endogenous and exogenous photoacoustic contrast agents effectively enable molecular imaging within deep tissues, their broad absorption spectra in the visible to near-infrared (NIR) range limit photoacoustic multiplexed imaging. Here, we exploit the distinct ultrasharp NIR absorption peaks of lanthanides to engineer a series of NIR photoacoustic nanocrystals. This engineering involves precise host and dopant material composition, yielding nanocrystals with sharply peaked photoacoustic absorption spectra (~3.2 nm width) and a ~10-fold enhancement in NIR optical absorption for efficient deep tissue imaging. By combining photoacoustic tomography with these engineered nanocrystals, we demonstrate photoacoustic multiplexed differential imaging with substantially decreased background signals and enhanced precision and contrast. |
| first_indexed | 2025-03-09T12:52:06Z |
| format | Journal Article |
| id | ntu-10356/181311 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-03-09T12:52:06Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1813112024-11-25T15:36:17Z Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging Loh, Kang Yong Li, Lei S. Fan, Jingyue Goh, Yi Yiing Liew, Weng Heng Davis, Samuel Zhang, Yide Li, Kai Liu, Jie Liang, Liangliang Feng, Minjun Yang, Ming Zhang, Hang Ma, Ping’an Feng, Guangxue Mu, Zhao Gao, Weibo Sum, Tze Chien Liu, Bin Lin, Jun Yao, Kui Wang, Lihong V. Liu, Xiaogang School of Physical and Mathematical Sciences The Photonics Institute Centre for Disruptive Photonic Technologies (CDPT) Physics Acoustics waves Photoacoustic tomography Photoacoustic tomography offers a powerful tool to visualize biologically relevant molecules and understand processes within living systems at high resolution in deep tissue, facilitated by the conversion of incident photons into low-scattering acoustic waves through non-radiative relaxation. Although current endogenous and exogenous photoacoustic contrast agents effectively enable molecular imaging within deep tissues, their broad absorption spectra in the visible to near-infrared (NIR) range limit photoacoustic multiplexed imaging. Here, we exploit the distinct ultrasharp NIR absorption peaks of lanthanides to engineer a series of NIR photoacoustic nanocrystals. This engineering involves precise host and dopant material composition, yielding nanocrystals with sharply peaked photoacoustic absorption spectra (~3.2 nm width) and a ~10-fold enhancement in NIR optical absorption for efficient deep tissue imaging. By combining photoacoustic tomography with these engineered nanocrystals, we demonstrate photoacoustic multiplexed differential imaging with substantially decreased background signals and enhanced precision and contrast. Agency for Science, Technology and Research (A*STAR) National Research Foundation (NRF) Published version This work is supported by National Research Foundation, Prime Minister’s Office, Singapore under its Competitive Research Program (Award No. NRFCRP23-2019-0002) and under its NRF Investigatorship Programme (Award No. NRF-NRFI05-2019-0003), the RIE2025 Manufacturing, Trade and Connectivity (MTC) Programmatic Fund (Award No. M21J9b0085), and National Institutes of Health, United States, grants U01 NS099717 (BRAIN Initiative) and R01 EB028277A, the internal fund F10000205 from Rice University, the Basic Science Center Program for Ordered Energy Conversion of the National Natural Science Foundation of China (No. 51888103), National Natural Science Foundation of China (51606192) and the CAS Pioneer Hundred Talents Program. Partial supports by A*STAR, Singapore, RIE2020 Advanced Manufacturing and Engineering (AME) Programmatic Fund (Grant No. A20G9b0135) are acknowledged. 2024-11-25T04:43:28Z 2024-11-25T04:43:28Z 2024 Journal Article Loh, K. Y., Li, L. S., Fan, J., Goh, Y. Y., Liew, W. H., Davis, S., Zhang, Y., Li, K., Liu, J., Liang, L., Feng, M., Yang, M., Zhang, H., Ma, P., Feng, G., Mu, Z., Gao, W., Sum, T. C., Liu, B., ...Liu, X. (2024). Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging. Communications Materials, 5(1), 164-. https://dx.doi.org/10.1038/s43246-024-00605-1 2662-4443 https://hdl.handle.net/10356/181311 10.1038/s43246-024-00605-1 2-s2.0-85201701055 1 5 164 en NRFCRP23-2019-0002 NRF-NRFI05-2019-0003 M21J9b0085 A20G9b0135 Communications Materials © 2024 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. application/pdf |
| spellingShingle | Physics Acoustics waves Photoacoustic tomography Loh, Kang Yong Li, Lei S. Fan, Jingyue Goh, Yi Yiing Liew, Weng Heng Davis, Samuel Zhang, Yide Li, Kai Liu, Jie Liang, Liangliang Feng, Minjun Yang, Ming Zhang, Hang Ma, Ping’an Feng, Guangxue Mu, Zhao Gao, Weibo Sum, Tze Chien Liu, Bin Lin, Jun Yao, Kui Wang, Lihong V. Liu, Xiaogang Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging |
| title | Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging |
| title_full | Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging |
| title_fullStr | Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging |
| title_full_unstemmed | Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging |
| title_short | Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging |
| title_sort | sharp peaked lanthanide nanocrystals for near infrared photoacoustic multiplexed differential imaging |
| topic | Physics Acoustics waves Photoacoustic tomography |
| url | https://hdl.handle.net/10356/181311 |
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