Transfusion of blood products and clinical outcomes for patients with dengue fever: a systematic review and meta-analysis
Background: This systematic review and meta-analysis aimed to analyze the effects of transfusing “nonpacked red blood cell” blood products in patients with dengue and evaluate the effectiveness in reducing mean hospital stay, bleeding, mortality rate, and intensive care unit requirements. Methods: F...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2024
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| Online Access: | https://hdl.handle.net/10356/181443 |
| _version_ | 1826127769240600576 |
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| author | Goh, Zhi Jie Li, Ruiqi Wang, Min Xian Chia, Po Ying Lim, Jue Tao |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Goh, Zhi Jie Li, Ruiqi Wang, Min Xian Chia, Po Ying Lim, Jue Tao |
| author_sort | Goh, Zhi Jie |
| collection | NTU |
| description | Background: This systematic review and meta-analysis aimed to analyze the effects of transfusing “nonpacked red blood cell” blood products in patients with dengue and evaluate the effectiveness in reducing mean hospital stay, bleeding, mortality rate, and intensive care unit requirements. Methods: Four databases were searched for relevant articles. Inclusion criteria were prospective or retrospective randomized or nonrandomized studies investigating the effects of transfusion of blood products in patients with dengue. Results: Nine studies were included in the final meta-analysis. Transfusion of blood products was associated with significantly higher mortality rate (9 studies; odds ratio [OR], 3.59 [95% confidence interval [CI], 1.07–15.98]; I2 = 0%; P = .04) and significantly longer mean hospital stay (6 studies; 0.56 day [95% CI, .03–1.08 day]; I2 = 95%; P = .04). There was no significant difference in the incidence of clinical bleeding (7 studies; OR, 1.13 [95% CI, .77–1.65]; I2 = 39%; P = .54) or intensive care unit requirement (3 studies; OR, 1.59 [.40–6.39]; I2 = 0%; P = .51). Conclusions: Transfusing blood products for patients with dengue showed no benefit and may even be harmful. |
| first_indexed | 2025-03-09T14:39:11Z |
| format | Journal Article |
| id | ntu-10356/181443 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-03-09T14:39:11Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | ntu-10356/1814432024-12-08T15:39:19Z Transfusion of blood products and clinical outcomes for patients with dengue fever: a systematic review and meta-analysis Goh, Zhi Jie Li, Ruiqi Wang, Min Xian Chia, Po Ying Lim, Jue Tao Lee Kong Chian School of Medicine (LKCMedicine) National Centre for Infectious Diseases, Singapore Tan Tock Seng Hospital Medicine, Health and Life Sciences Blood product transfusion Dengue fever Background: This systematic review and meta-analysis aimed to analyze the effects of transfusing “nonpacked red blood cell” blood products in patients with dengue and evaluate the effectiveness in reducing mean hospital stay, bleeding, mortality rate, and intensive care unit requirements. Methods: Four databases were searched for relevant articles. Inclusion criteria were prospective or retrospective randomized or nonrandomized studies investigating the effects of transfusion of blood products in patients with dengue. Results: Nine studies were included in the final meta-analysis. Transfusion of blood products was associated with significantly higher mortality rate (9 studies; odds ratio [OR], 3.59 [95% confidence interval [CI], 1.07–15.98]; I2 = 0%; P = .04) and significantly longer mean hospital stay (6 studies; 0.56 day [95% CI, .03–1.08 day]; I2 = 95%; P = .04). There was no significant difference in the incidence of clinical bleeding (7 studies; OR, 1.13 [95% CI, .77–1.65]; I2 = 39%; P = .54) or intensive care unit requirement (3 studies; OR, 1.59 [.40–6.39]; I2 = 0%; P = .51). Conclusions: Transfusing blood products for patients with dengue showed no benefit and may even be harmful. Published version 2024-12-02T06:34:14Z 2024-12-02T06:34:14Z 2024 Journal Article Goh, Z. J., Li, R., Wang, M. X., Chia, P. Y. & Lim, J. T. (2024). Transfusion of blood products and clinical outcomes for patients with dengue fever: a systematic review and meta-analysis. Open Forum Infectious Diseases, 11(9), ofae507-. https://dx.doi.org/10.1093/ofid/ofae507 2328-8957 https://hdl.handle.net/10356/181443 10.1093/ofid/ofae507 39319088 2-s2.0-85204919615 9 11 ofae507 en Open Forum Infectious Diseases © 2024 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf |
| spellingShingle | Medicine, Health and Life Sciences Blood product transfusion Dengue fever Goh, Zhi Jie Li, Ruiqi Wang, Min Xian Chia, Po Ying Lim, Jue Tao Transfusion of blood products and clinical outcomes for patients with dengue fever: a systematic review and meta-analysis |
| title | Transfusion of blood products and clinical outcomes for patients with dengue fever: a systematic review and meta-analysis |
| title_full | Transfusion of blood products and clinical outcomes for patients with dengue fever: a systematic review and meta-analysis |
| title_fullStr | Transfusion of blood products and clinical outcomes for patients with dengue fever: a systematic review and meta-analysis |
| title_full_unstemmed | Transfusion of blood products and clinical outcomes for patients with dengue fever: a systematic review and meta-analysis |
| title_short | Transfusion of blood products and clinical outcomes for patients with dengue fever: a systematic review and meta-analysis |
| title_sort | transfusion of blood products and clinical outcomes for patients with dengue fever a systematic review and meta analysis |
| topic | Medicine, Health and Life Sciences Blood product transfusion Dengue fever |
| url | https://hdl.handle.net/10356/181443 |
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