SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening

SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2, SARS2) is responsible for the COVID-19 pandemic and infections that continue to affect the lives of millions of people worldwide, especially those who are older and/or immunocompromised. The SARS2 main protease enzyme, Mpro (also called 3C...

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Bibliographic Details
Main Authors: Delgado, Renee, Vishwakarma, Jyoti, Moghadasi, Seyed Arad, Otsuka, Yuka, Shumate, Justin, Cuell, Ashley, Tansiongco, Megan, Cooley, Christina B., Chen, Yanjun, Dabrowska, Agnieszka, Basu, Rahul, Anindita, Paulina Duhita, Luo, Dahai, Dosa, Peter I., Harki, Daniel A., Bannister, Thomas, Scampavia, Louis, Spicer, Timothy P., Harris, Reuben S.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Antiviral drugs
Cell-based ultra-high throughput screening
Online Access:https://hdl.handle.net/10356/181907

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