Curcumin-loaded bacterial cellulose films suppress in vitro melanogenesis in human epidermal melanocytes
Efficacious dosage of conventional hyperpigmentation treatments is limited by their toxicity and undesirable side effects. Bacterial cellulose (BC) patch containing plant phenolic compound is proposed as an effective yet safe alternative. In this work, curcumin-loaded BC film (Cur(BC)) was develope...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/182034 |
| _version_ | 1824454052238327808 |
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| author | Gopal, Maanasa Pham, Vuong Minh Sundaravadanam, Vishnu Vadanan Dang, Tram Thuy Lim, Sierin |
| author2 | School of Chemistry, Chemical Engineering and Biotechnology |
| author_facet | School of Chemistry, Chemical Engineering and Biotechnology Gopal, Maanasa Pham, Vuong Minh Sundaravadanam, Vishnu Vadanan Dang, Tram Thuy Lim, Sierin |
| author_sort | Gopal, Maanasa |
| collection | NTU |
| description | Efficacious dosage of conventional hyperpigmentation treatments is limited by their toxicity and undesirable side effects. Bacterial cellulose (BC) patch containing plant phenolic compound is proposed as an effective yet safe alternative. In this work, curcumin-loaded BC film (Cur(BC)) was developed as a cytocompatible inhibitor of in vitro melanogenesis in hyperpigmented melanocytes. (Cur)BC was characterized to understand its morphological, physical, and chemical properties. Its anti-melanogenic effects were assessed by in vitro studies performed on putrescine induced human epidermal melanocytes. Results show that Cur(BC) is non-cytotoxic, decreases melanin production by up to 58%, and down-regulates melanogenesis-related genes TYR, TRP-1, TRP-2. This report features the first evaluation of the synergistic effects and limitations of curcumin-loaded bacterial cellulose composites on melanin production in vitro. |
| first_indexed | 2025-02-19T03:16:11Z |
| format | Journal Article |
| id | ntu-10356/182034 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:16:11Z |
| publishDate | 2025 |
| record_format | dspace |
| spelling | ntu-10356/1820342025-01-13T06:32:35Z Curcumin-loaded bacterial cellulose films suppress in vitro melanogenesis in human epidermal melanocytes Gopal, Maanasa Pham, Vuong Minh Sundaravadanam, Vishnu Vadanan Dang, Tram Thuy Lim, Sierin School of Chemistry, Chemical Engineering and Biotechnology Engineering Pigmentation Melanocytes Efficacious dosage of conventional hyperpigmentation treatments is limited by their toxicity and undesirable side effects. Bacterial cellulose (BC) patch containing plant phenolic compound is proposed as an effective yet safe alternative. In this work, curcumin-loaded BC film (Cur(BC)) was developed as a cytocompatible inhibitor of in vitro melanogenesis in hyperpigmented melanocytes. (Cur)BC was characterized to understand its morphological, physical, and chemical properties. Its anti-melanogenic effects were assessed by in vitro studies performed on putrescine induced human epidermal melanocytes. Results show that Cur(BC) is non-cytotoxic, decreases melanin production by up to 58%, and down-regulates melanogenesis-related genes TYR, TRP-1, TRP-2. This report features the first evaluation of the synergistic effects and limitations of curcumin-loaded bacterial cellulose composites on melanin production in vitro. 2025-01-13T06:32:04Z 2025-01-13T06:32:04Z 2024 Journal Article Gopal, M., Pham, V. M., Sundaravadanam, V. V., Dang, T. T. & Lim, S. (2024). Curcumin-loaded bacterial cellulose films suppress in vitro melanogenesis in human epidermal melanocytes. Cellulose. https://dx.doi.org/10.1007/s10570-024-06208-w 0969-0239 https://hdl.handle.net/10356/182034 10.1007/s10570-024-06208-w en Cellulose © 2024 The Author(s), under exclusive licence to Springer Nature B.V. All rights reserved. |
| spellingShingle | Engineering Pigmentation Melanocytes Gopal, Maanasa Pham, Vuong Minh Sundaravadanam, Vishnu Vadanan Dang, Tram Thuy Lim, Sierin Curcumin-loaded bacterial cellulose films suppress in vitro melanogenesis in human epidermal melanocytes |
| title | Curcumin-loaded bacterial cellulose films suppress in vitro melanogenesis in human epidermal melanocytes |
| title_full | Curcumin-loaded bacterial cellulose films suppress in vitro melanogenesis in human epidermal melanocytes |
| title_fullStr | Curcumin-loaded bacterial cellulose films suppress in vitro melanogenesis in human epidermal melanocytes |
| title_full_unstemmed | Curcumin-loaded bacterial cellulose films suppress in vitro melanogenesis in human epidermal melanocytes |
| title_short | Curcumin-loaded bacterial cellulose films suppress in vitro melanogenesis in human epidermal melanocytes |
| title_sort | curcumin loaded bacterial cellulose films suppress in vitro melanogenesis in human epidermal melanocytes |
| topic | Engineering Pigmentation Melanocytes |
| url | https://hdl.handle.net/10356/182034 |
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