High extracellular K+ skews T-cell differentiation towards tumour promoting Th2 and Treg subsets

High extracellular K+ skews T-cell differentiation towards tumour promoting Th2 and Treg subsets

Potassium ions (K+) released from dying necrotic tumour cells accumulate in the tumour microenvironment (TME) and increase the local K+ concentration to 50 mM (high-[K+]e). Here, we demonstrate that high-[K+]e decreases expression of the T-cell receptor subunits CD3ε and CD3ζ and co-stimulatory rece...

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Bibliographic Details
Main Authors: Wong, Brandon Han Siang, Poh, Zhi Sheng, Tan, James Chia Wei, Amuthavalli, Kottaiswamy, Ho, Ying Swan, Chen, Shuwen, Mak, Shi Ya, Bi, Xuezhi, Webster, Richard David, Shelat, Vishalkumar G., Chandy, Kanianthara George, Verma, Navin Kumar
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2025
Subjects:
Medicine, Health and Life Sciences
Immune suppression
Metabolomics
Online Access:https://hdl.handle.net/10356/182492

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