Promoting piezoelectricity in amino acids by fluorination
Bioinspired piezoelectric amino acids and peptides are attracting attention due to their designable sequences, versatile structures, low cost, and biodegradability. However, it remains a challenge to design amino acids and peptides with high piezoelectricity. Herein, a high piezoelectric amino acid...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2025
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| Online Access: | https://hdl.handle.net/10356/182514 |
| _version_ | 1826124532305362944 |
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| author | Hu, Tan Lee, Jin Pyo Huang, Peiwen Ong, Amanda Jiamin Yu, Jian Zhu, Shuihong Jiang, Yixuan Zhang, Zhuo Reches, Meital Lee, Pooi See |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Hu, Tan Lee, Jin Pyo Huang, Peiwen Ong, Amanda Jiamin Yu, Jian Zhu, Shuihong Jiang, Yixuan Zhang, Zhuo Reches, Meital Lee, Pooi See |
| author_sort | Hu, Tan |
| collection | NTU |
| description | Bioinspired piezoelectric amino acids and peptides are attracting attention due to their designable sequences, versatile structures, low cost, and biodegradability. However, it remains a challenge to design amino acids and peptides with high piezoelectricity. Herein, a high piezoelectric amino acid by simple fluorination in its side chain is presented. The three phenylalanine derivatives are designed: Cbz-Phe, Cbz-Phe(4F), and Cbz-pentafluoro-Phe. The effect of fluorination on self-assembly and piezoelectricity is investigated. Cbz-Phe(4F) can self-assemble into crystals with a C2 space group, while Cbz-Phe and Cbz-pentafluoro-Phe form aggregated self-assemblies. Moreover, Cbz-Phe(4F) crystals exhibit a remarkably higher piezoelectric coefficient ( d33eff$d_{\ 33}^{\ eff}$ ) of ≈17.9 pm V-1 than Cbz-Phe and Cbz-pentafluoro-Phe. When fabricated as a piezoelectric nanogenerator, it generates an open-circuit voltage of ≈2.4 V. Importantly, Cbz-Phe(4F) crystals serve as a flexible piezoelectric sensor for the classification of various nuts and their quality sorting, which includes those as small as individual pumpkin seeds with high sensitivity and accuracy of sorting and quality checks. When mounted onto soft grippers, the sensor performs the tactile self-sensing functions. This work provides a promising approach to designing high piezoelectric amino acids by simple fluorination, offering exciting prospects for advancements in bioinspired piezoelectric materials in the application of smart agriculture and soft robotics. |
| first_indexed | 2025-03-09T13:47:45Z |
| format | Journal Article |
| id | ntu-10356/182514 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-03-09T13:47:45Z |
| publishDate | 2025 |
| record_format | dspace |
| spelling | ntu-10356/1825142025-02-05T06:02:41Z Promoting piezoelectricity in amino acids by fluorination Hu, Tan Lee, Jin Pyo Huang, Peiwen Ong, Amanda Jiamin Yu, Jian Zhu, Shuihong Jiang, Yixuan Zhang, Zhuo Reches, Meital Lee, Pooi See School of Materials Science and Engineering Singapore-HUJ Alliance for Research and Enterprise Engineering Fexible piezoelectric sensors Fuorination Bioinspired piezoelectric amino acids and peptides are attracting attention due to their designable sequences, versatile structures, low cost, and biodegradability. However, it remains a challenge to design amino acids and peptides with high piezoelectricity. Herein, a high piezoelectric amino acid by simple fluorination in its side chain is presented. The three phenylalanine derivatives are designed: Cbz-Phe, Cbz-Phe(4F), and Cbz-pentafluoro-Phe. The effect of fluorination on self-assembly and piezoelectricity is investigated. Cbz-Phe(4F) can self-assemble into crystals with a C2 space group, while Cbz-Phe and Cbz-pentafluoro-Phe form aggregated self-assemblies. Moreover, Cbz-Phe(4F) crystals exhibit a remarkably higher piezoelectric coefficient ( d33eff$d_{\ 33}^{\ eff}$ ) of ≈17.9 pm V-1 than Cbz-Phe and Cbz-pentafluoro-Phe. When fabricated as a piezoelectric nanogenerator, it generates an open-circuit voltage of ≈2.4 V. Importantly, Cbz-Phe(4F) crystals serve as a flexible piezoelectric sensor for the classification of various nuts and their quality sorting, which includes those as small as individual pumpkin seeds with high sensitivity and accuracy of sorting and quality checks. When mounted onto soft grippers, the sensor performs the tactile self-sensing functions. This work provides a promising approach to designing high piezoelectric amino acids by simple fluorination, offering exciting prospects for advancements in bioinspired piezoelectric materials in the application of smart agriculture and soft robotics. National Research Foundation (NRF) This research is supported by grants from the National Research Foundation, Prime Minister’s Office, Singapore under its Campus of Research Excellence and Technological Enterprise (CREATE) program (grant No. SGSR CREATE). Z.Z. would like to thank for the support of the National Natural Science Foundation of China (32172350). 2025-02-05T06:02:41Z 2025-02-05T06:02:41Z 2025 Journal Article Hu, T., Lee, J. P., Huang, P., Ong, A. J., Yu, J., Zhu, S., Jiang, Y., Zhang, Z., Reches, M. & Lee, P. S. (2025). Promoting piezoelectricity in amino acids by fluorination. Advanced Materials, 37(3), e2413049-. https://dx.doi.org/10.1002/adma.202413049 0935-9648 https://hdl.handle.net/10356/182514 10.1002/adma.202413049 39551989 2-s2.0-85209138122 3 37 e2413049 en SGSR CREATE Advanced Materials © 2024 Wiley-VCH GmbH. All rights reserved. |
| spellingShingle | Engineering Fexible piezoelectric sensors Fuorination Hu, Tan Lee, Jin Pyo Huang, Peiwen Ong, Amanda Jiamin Yu, Jian Zhu, Shuihong Jiang, Yixuan Zhang, Zhuo Reches, Meital Lee, Pooi See Promoting piezoelectricity in amino acids by fluorination |
| title | Promoting piezoelectricity in amino acids by fluorination |
| title_full | Promoting piezoelectricity in amino acids by fluorination |
| title_fullStr | Promoting piezoelectricity in amino acids by fluorination |
| title_full_unstemmed | Promoting piezoelectricity in amino acids by fluorination |
| title_short | Promoting piezoelectricity in amino acids by fluorination |
| title_sort | promoting piezoelectricity in amino acids by fluorination |
| topic | Engineering Fexible piezoelectric sensors Fuorination |
| url | https://hdl.handle.net/10356/182514 |
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