Nano-vesicles for gene delivery
Gene therapy was considered an important modality for the potential treatment of cancer. It aimed to correct diseases through the delivery of genetic material encoding a therapeutic protein and the subsequent expression of the transgene at the appropriate sites. The hurdle for effective gene therapy...
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| Format: | Thesis |
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2008
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| Online Access: | https://hdl.handle.net/10356/2194 |
| _version_ | 1826114612149354496 |
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| author | Tan, Karen Li Ping |
| author2 | Cheang Hong Ning, Philip |
| author_facet | Cheang Hong Ning, Philip Tan, Karen Li Ping |
| author_sort | Tan, Karen Li Ping |
| collection | NTU |
| description | Gene therapy was considered an important modality for the potential treatment of cancer. It aimed to correct diseases through the delivery of genetic material encoding a therapeutic protein and the subsequent expression of the transgene at the appropriate sites. The hurdle for effective gene therapy hinged on the development of safe vectors that have the ability to efficiently deliver therapeutic DNA to the targeted site. In this study, the potential applications of nano-bioceramics for gene delivery were investigated. Nano-sized bio-ceramic particles including neutrally charged hydroxyapatite (HA), negatively charged silica (SiO2) and positively charged zirconia (ZrO2) were tested. |
| first_indexed | 2024-10-01T03:41:55Z |
| format | Thesis |
| id | ntu-10356/2194 |
| institution | Nanyang Technological University |
| last_indexed | 2024-10-01T03:41:55Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | ntu-10356/21942023-03-03T15:59:23Z Nano-vesicles for gene delivery Tan, Karen Li Ping Cheang Hong Ning, Philip School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Biomedical engineering Gene therapy was considered an important modality for the potential treatment of cancer. It aimed to correct diseases through the delivery of genetic material encoding a therapeutic protein and the subsequent expression of the transgene at the appropriate sites. The hurdle for effective gene therapy hinged on the development of safe vectors that have the ability to efficiently deliver therapeutic DNA to the targeted site. In this study, the potential applications of nano-bioceramics for gene delivery were investigated. Nano-sized bio-ceramic particles including neutrally charged hydroxyapatite (HA), negatively charged silica (SiO2) and positively charged zirconia (ZrO2) were tested. MASTER OF ENGINEERING (SCBE) 2008-09-16T06:49:24Z 2008-09-16T06:49:24Z 2006 2006 Thesis Tan, K. L. P. (2006). Nano-vesicles for gene delivery. Master’s thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/2194 10.32657/10356/2194 Nanyang Technological University application/pdf |
| spellingShingle | DRNTU::Science::Medicine::Biomedical engineering Tan, Karen Li Ping Nano-vesicles for gene delivery |
| title | Nano-vesicles for gene delivery |
| title_full | Nano-vesicles for gene delivery |
| title_fullStr | Nano-vesicles for gene delivery |
| title_full_unstemmed | Nano-vesicles for gene delivery |
| title_short | Nano-vesicles for gene delivery |
| title_sort | nano vesicles for gene delivery |
| topic | DRNTU::Science::Medicine::Biomedical engineering |
| url | https://hdl.handle.net/10356/2194 |
| work_keys_str_mv | AT tankarenliping nanovesiclesforgenedelivery |