Synthesis of natural products by intramolecular Michael addition
The intramolecular hetero-Michael addition is one of the most convergent strategies for the synthesis of six membered heterocyclic rings from α,β-unsaturated carbonyl compounds. However, the selection of suitable precursors for the Michael addition so as to provide the efficient stereocontrol is sti...
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| Format: | Thesis |
| Language: | English |
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2010
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| Online Access: | https://hdl.handle.net/10356/22909 |
| Summary: | The intramolecular hetero-Michael addition is one of the most convergent strategies for the synthesis of six membered heterocyclic rings from α,β-unsaturated carbonyl compounds. However, the selection of suitable precursors for the Michael addition so as to provide the efficient stereocontrol is still a challenging issue and seldom reported in the literature. The emphasis of this thesis is placed on the investigation of efficient stereochemistry control in the synthesis of natural products such as (-)-monomorine (I), diospongin A and clavosolide A. The emphasis of this thesis is placed on the investigation of efficient stereochemistry control in the synthesis of natural products such as (-)-monomorine (I), diospongin A and clavosolide A. |
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