Multidimensional signal processing of NMR data
Although significant progress has been achieved in sequencing the human genome in recent years, the molecular basis for many diseases can only be understood if the three-dimensional (3D) structures of the proteins encoded by genes are available. Sequencing a gene is nowadays essentially a routine ta...
| Main Authors: | , , |
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| Format: | Research Report |
| Published: |
2008
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| Online Access: | http://hdl.handle.net/10356/2920 |
| _version_ | 1826127769862406144 |
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| author | Lin, Zhiping Raimund J. Ober E. Sally Ward |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Lin, Zhiping Raimund J. Ober E. Sally Ward |
| author_sort | Lin, Zhiping |
| collection | NTU |
| description | Although significant progress has been achieved in sequencing the human genome in recent years, the molecular basis for many diseases can only be understood if the three-dimensional (3D) structures of the proteins encoded by genes are available. Sequencing a gene is nowadays essentially a routine task, whereas the determination of a 3D structure of a protein is still a major task that will typically take years to complete. Currently, nuclear magnetic resonance (NMR) spectroscopy is still one of the two major methods for the determination of 3D protein structures as other methods are still not very accurate The processing and analysis of multidimensional (nD) NMR data is an important step in NMR spectroscopy. There are several methods for processing nD NMR data, but they are mainly based on the one-dimensional (1D) techniques. Moreover, there does not exist any rigorous measure for assessing how good the existing methods for estimating the NMR parameters. In this project, we analyze and process nD NMR data using nD system theory and signal processing techniques and global optimization methods. An important step in our investigation is to interprete nD NMR data as the impulse response of a separable nD state space system. |
| first_indexed | 2024-10-01T07:14:16Z |
| format | Research Report |
| id | ntu-10356/2920 |
| institution | Nanyang Technological University |
| last_indexed | 2024-10-01T07:14:16Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | ntu-10356/29202023-03-04T03:23:49Z Multidimensional signal processing of NMR data Lin, Zhiping Raimund J. Ober E. Sally Ward School of Electrical and Electronic Engineering DRNTU::Engineering::Electrical and electronic engineering::Electronic systems::Signal processing Although significant progress has been achieved in sequencing the human genome in recent years, the molecular basis for many diseases can only be understood if the three-dimensional (3D) structures of the proteins encoded by genes are available. Sequencing a gene is nowadays essentially a routine task, whereas the determination of a 3D structure of a protein is still a major task that will typically take years to complete. Currently, nuclear magnetic resonance (NMR) spectroscopy is still one of the two major methods for the determination of 3D protein structures as other methods are still not very accurate The processing and analysis of multidimensional (nD) NMR data is an important step in NMR spectroscopy. There are several methods for processing nD NMR data, but they are mainly based on the one-dimensional (1D) techniques. Moreover, there does not exist any rigorous measure for assessing how good the existing methods for estimating the NMR parameters. In this project, we analyze and process nD NMR data using nD system theory and signal processing techniques and global optimization methods. An important step in our investigation is to interprete nD NMR data as the impulse response of a separable nD state space system. 2008-09-17T09:17:13Z 2008-09-17T09:17:13Z 2004 2004 Research Report http://hdl.handle.net/10356/2920 Nanyang Technological University application/pdf |
| spellingShingle | DRNTU::Engineering::Electrical and electronic engineering::Electronic systems::Signal processing Lin, Zhiping Raimund J. Ober E. Sally Ward Multidimensional signal processing of NMR data |
| title | Multidimensional signal processing of NMR data |
| title_full | Multidimensional signal processing of NMR data |
| title_fullStr | Multidimensional signal processing of NMR data |
| title_full_unstemmed | Multidimensional signal processing of NMR data |
| title_short | Multidimensional signal processing of NMR data |
| title_sort | multidimensional signal processing of nmr data |
| topic | DRNTU::Engineering::Electrical and electronic engineering::Electronic systems::Signal processing |
| url | http://hdl.handle.net/10356/2920 |
| work_keys_str_mv | AT linzhiping multidimensionalsignalprocessingofnmrdata AT raimundjober multidimensionalsignalprocessingofnmrdata AT esallyward multidimensionalsignalprocessingofnmrdata |