Design of computerized drug delivery control system
Postsurgical complication of hypertension may occur in cardiac patients. This is particularly evident after coronary artery bypass grafting procedures. To decrease the chances of complication, it is necessary to reduce the elevated blood pressure as soon as possible. One of effective way is continuo...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Research Report |
| Published: |
2008
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| Online Access: | http://hdl.handle.net/10356/2921 |
| _version_ | 1826124983944871936 |
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| author | Krishnan Shankar Muthu. Tan, Yong Seng. Zhu, Kuanyi. |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Krishnan Shankar Muthu. Tan, Yong Seng. Zhu, Kuanyi. |
| author_sort | Krishnan Shankar Muthu. |
| collection | NTU |
| description | Postsurgical complication of hypertension may occur in cardiac patients. This is particularly evident after coronary artery bypass grafting procedures. To decrease the chances of complication, it is necessary to reduce the elevated blood pressure as soon as possible. One of effective way is continuous infusion of vasodilator drugs, such as sodium nitroprusside (SNP), which will quickly lower the blood pressure in most patients. However, it is observed that a wide range of patient drug sensitivities to SNP occurs and also, critical patient care often requires the infusion of blood, fluid, or drugs to regulate cardiovascular system variables. Even though manual control by clinical personnel could be very tedious, time consuming and inconsistent, it is the current situation. It is believed therefore, that automation of these therapies by application of feedback control techniques can be effective. In this project, we propose some control methods to regulate the infusion rate of vasodilator drug so that the desired mean arterial pressure can be reached. An adaptive control algorithm based on generalized predictive control is designed. Following that, a new PI controller is proposed and a new control criterion for switching from one controller to another has been introduced. |
| first_indexed | 2024-10-01T06:29:18Z |
| format | Research Report |
| id | ntu-10356/2921 |
| institution | Nanyang Technological University |
| last_indexed | 2024-10-01T06:29:18Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | ntu-10356/29212023-03-04T03:23:09Z Design of computerized drug delivery control system Krishnan Shankar Muthu. Tan, Yong Seng. Zhu, Kuanyi. School of Electrical and Electronic Engineering DRNTU::Engineering::Electrical and electronic engineering::Control and instrumentation::Medical electronics Postsurgical complication of hypertension may occur in cardiac patients. This is particularly evident after coronary artery bypass grafting procedures. To decrease the chances of complication, it is necessary to reduce the elevated blood pressure as soon as possible. One of effective way is continuous infusion of vasodilator drugs, such as sodium nitroprusside (SNP), which will quickly lower the blood pressure in most patients. However, it is observed that a wide range of patient drug sensitivities to SNP occurs and also, critical patient care often requires the infusion of blood, fluid, or drugs to regulate cardiovascular system variables. Even though manual control by clinical personnel could be very tedious, time consuming and inconsistent, it is the current situation. It is believed therefore, that automation of these therapies by application of feedback control techniques can be effective. In this project, we propose some control methods to regulate the infusion rate of vasodilator drug so that the desired mean arterial pressure can be reached. An adaptive control algorithm based on generalized predictive control is designed. Following that, a new PI controller is proposed and a new control criterion for switching from one controller to another has been introduced. 2008-09-17T09:17:15Z 2008-09-17T09:17:15Z 2004 2004 Research Report http://hdl.handle.net/10356/2921 Nanyang Technological University application/pdf |
| spellingShingle | DRNTU::Engineering::Electrical and electronic engineering::Control and instrumentation::Medical electronics Krishnan Shankar Muthu. Tan, Yong Seng. Zhu, Kuanyi. Design of computerized drug delivery control system |
| title | Design of computerized drug delivery control system |
| title_full | Design of computerized drug delivery control system |
| title_fullStr | Design of computerized drug delivery control system |
| title_full_unstemmed | Design of computerized drug delivery control system |
| title_short | Design of computerized drug delivery control system |
| title_sort | design of computerized drug delivery control system |
| topic | DRNTU::Engineering::Electrical and electronic engineering::Control and instrumentation::Medical electronics |
| url | http://hdl.handle.net/10356/2921 |
| work_keys_str_mv | AT krishnanshankarmuthu designofcomputerizeddrugdeliverycontrolsystem AT tanyongseng designofcomputerizeddrugdeliverycontrolsystem AT zhukuanyi designofcomputerizeddrugdeliverycontrolsystem |