Formulation of an anti-inflammatory drug using pH responsive poly(methacrylic acid)(PMAA)-graft-hollow silica for oral drug delivery
pH responsive properties of poly(methacrylic acid) (PMAA) grafted nano-sized hollow silica (PMAA-g-HSi) were characterized, and better formulation of sulfasalazine (an anti-inflammatory pro-drug used for bowel disease) was pursued using PMAA-g-HSi. To investigate pH responsive behaviour of PMAA-g...
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| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2010
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| Online Access: | http://hdl.handle.net/10356/35521 |
| _version_ | 1826125561148211200 |
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| author | Kong, Wai Tuck. |
| author2 | Hu Xiao |
| author_facet | Hu Xiao Kong, Wai Tuck. |
| author_sort | Kong, Wai Tuck. |
| collection | NTU |
| description | pH responsive properties of poly(methacrylic acid) (PMAA) grafted nano-sized
hollow silica (PMAA-g-HSi) were characterized, and better formulation of
sulfasalazine (an anti-inflammatory pro-drug used for bowel disease) was pursued
using PMAA-g-HSi. To investigate pH responsive behaviour of PMAA-g-HSi,
fluorescein-isothiocyanate-dextran (FITC-dextran), was used a probe and the release
profile of FITC-dextran was monitored using fluorescence spectrometer. It was
found that FITC-dextran loaded into PMAA-g-HSi was retained in the PMAA-g-
HSi under acidic condition (pH2) for as long as 24h. However, FITC-dextran was
released in a single burst release when pH was increased to above 7. In order to get
better formulation of sulfasalazine with target delivery site at intestine (pH > 7) and
without drug loss and degradation at acidic stomach (pH <3), pH responsive PMAAg-
HSi was applied for encapsulation of sulfasalazine. Factors including drug
concentration, ultra-sonication time, and drug recycling, on the drug loading
capacity were investigated using UV spectroscopy. Also pH dependent release
profile of sulfasalazine from PMAA-g-HSi was monitored using UV spectroscopy.
It was shown that sulfasalazine was kept in PMAA-g-HSi at pH <2 but was released
out at pH > 7. So PMAA-g-HSi is promising for better formulation of sulfasalazine. |
| first_indexed | 2024-10-01T06:38:40Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/35521 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:38:40Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/355212023-03-04T15:30:36Z Formulation of an anti-inflammatory drug using pH responsive poly(methacrylic acid)(PMAA)-graft-hollow silica for oral drug delivery Kong, Wai Tuck. Hu Xiao School of Materials Science and Engineering A*STAR Institute of Material Research and Engineering Liu Ye DRNTU::Engineering::Materials::Biomaterials pH responsive properties of poly(methacrylic acid) (PMAA) grafted nano-sized hollow silica (PMAA-g-HSi) were characterized, and better formulation of sulfasalazine (an anti-inflammatory pro-drug used for bowel disease) was pursued using PMAA-g-HSi. To investigate pH responsive behaviour of PMAA-g-HSi, fluorescein-isothiocyanate-dextran (FITC-dextran), was used a probe and the release profile of FITC-dextran was monitored using fluorescence spectrometer. It was found that FITC-dextran loaded into PMAA-g-HSi was retained in the PMAA-g- HSi under acidic condition (pH2) for as long as 24h. However, FITC-dextran was released in a single burst release when pH was increased to above 7. In order to get better formulation of sulfasalazine with target delivery site at intestine (pH > 7) and without drug loss and degradation at acidic stomach (pH <3), pH responsive PMAAg- HSi was applied for encapsulation of sulfasalazine. Factors including drug concentration, ultra-sonication time, and drug recycling, on the drug loading capacity were investigated using UV spectroscopy. Also pH dependent release profile of sulfasalazine from PMAA-g-HSi was monitored using UV spectroscopy. It was shown that sulfasalazine was kept in PMAA-g-HSi at pH <2 but was released out at pH > 7. So PMAA-g-HSi is promising for better formulation of sulfasalazine. Bachelor of Engineering (Materials Engineering) 2010-04-20T04:11:45Z 2010-04-20T04:11:45Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/35521 en Nanyang Technological University 53 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Materials::Biomaterials Kong, Wai Tuck. Formulation of an anti-inflammatory drug using pH responsive poly(methacrylic acid)(PMAA)-graft-hollow silica for oral drug delivery |
| title | Formulation of an anti-inflammatory drug using pH responsive poly(methacrylic acid)(PMAA)-graft-hollow silica for oral drug delivery |
| title_full | Formulation of an anti-inflammatory drug using pH responsive poly(methacrylic acid)(PMAA)-graft-hollow silica for oral drug delivery |
| title_fullStr | Formulation of an anti-inflammatory drug using pH responsive poly(methacrylic acid)(PMAA)-graft-hollow silica for oral drug delivery |
| title_full_unstemmed | Formulation of an anti-inflammatory drug using pH responsive poly(methacrylic acid)(PMAA)-graft-hollow silica for oral drug delivery |
| title_short | Formulation of an anti-inflammatory drug using pH responsive poly(methacrylic acid)(PMAA)-graft-hollow silica for oral drug delivery |
| title_sort | formulation of an anti inflammatory drug using ph responsive poly methacrylic acid pmaa graft hollow silica for oral drug delivery |
| topic | DRNTU::Engineering::Materials::Biomaterials |
| url | http://hdl.handle.net/10356/35521 |
| work_keys_str_mv | AT kongwaituck formulationofanantiinflammatorydrugusingphresponsivepolymethacrylicacidpmaagrafthollowsilicafororaldrugdelivery |