New materials for drug delivery
The success of anti-cancer therapy largely depends on the development of high-efficient, low toxic, long-circulating, and cancer-targeted drug delivery systems. Nanoparticles (NPs), an evolution of nanotechnology, have the potential to successfully address the problems of current drug delivery techn...
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| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
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2010
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| Online Access: | http://hdl.handle.net/10356/35819 |
| _version_ | 1811683134294458368 |
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| author | Chua, Ming Fong. |
| author2 | Andrew Clive Grimsdale |
| author_facet | Andrew Clive Grimsdale Chua, Ming Fong. |
| author_sort | Chua, Ming Fong. |
| collection | NTU |
| description | The success of anti-cancer therapy largely depends on the development of high-efficient, low toxic, long-circulating, and cancer-targeted drug delivery systems. Nanoparticles (NPs), an evolution of nanotechnology, have the potential to successfully address the problems of current drug delivery techniques. Hence nanoparticles are considered as potential candidates to carry drugs to the desired site of therapeutic action.
This report focuses on the surface modification of nanoparticles through the use of surfactant Poly Vinyl Alcohol (PVA), Pyrophosphoric acid (PPA) and Bovine Serum Albumin (BSA). Surface modification of nanoparticles enhanced the attachment of targeted molecule with alkyne strycture through either one of its chain end namely; ester and amine functional group.
Successfully synthesized product was characterized through nuclear magnetic resonance (NMR) before their attachment to surface modified nanoparticles. Fourier Transform Infrared spectroscopy (FTIR) was used to characterise the resultant product between the attachments of targeted alkyne compound to nanoparticles. |
| first_indexed | 2024-10-01T04:07:54Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/35819 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:07:54Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | ntu-10356/358192023-03-04T15:35:29Z New materials for drug delivery Chua, Ming Fong. Andrew Clive Grimsdale School of Materials Science and Engineering DRNTU::Engineering The success of anti-cancer therapy largely depends on the development of high-efficient, low toxic, long-circulating, and cancer-targeted drug delivery systems. Nanoparticles (NPs), an evolution of nanotechnology, have the potential to successfully address the problems of current drug delivery techniques. Hence nanoparticles are considered as potential candidates to carry drugs to the desired site of therapeutic action. This report focuses on the surface modification of nanoparticles through the use of surfactant Poly Vinyl Alcohol (PVA), Pyrophosphoric acid (PPA) and Bovine Serum Albumin (BSA). Surface modification of nanoparticles enhanced the attachment of targeted molecule with alkyne strycture through either one of its chain end namely; ester and amine functional group. Successfully synthesized product was characterized through nuclear magnetic resonance (NMR) before their attachment to surface modified nanoparticles. Fourier Transform Infrared spectroscopy (FTIR) was used to characterise the resultant product between the attachments of targeted alkyne compound to nanoparticles. Bachelor of Engineering (Materials Engineering) 2010-04-23T01:45:53Z 2010-04-23T01:45:53Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/35819 en Nanyang Technological University 56 p. application/pdf |
| spellingShingle | DRNTU::Engineering Chua, Ming Fong. New materials for drug delivery |
| title | New materials for drug delivery |
| title_full | New materials for drug delivery |
| title_fullStr | New materials for drug delivery |
| title_full_unstemmed | New materials for drug delivery |
| title_short | New materials for drug delivery |
| title_sort | new materials for drug delivery |
| topic | DRNTU::Engineering |
| url | http://hdl.handle.net/10356/35819 |
| work_keys_str_mv | AT chuamingfong newmaterialsfordrugdelivery |